Decision tree, assessment

It is appropriate here to consider briefly some of the experimental approaches that are contained within such decision trees, and that continue to provide the bases for protein allergenicity safety assessment. 

The group has elaborated on their approach and provided a scheme (decision tree) for hazard identification and risk assessment of complex mixtures (Feron et al. 1998, Groten et al. 2001) (Figure 10.6). In this scheme it is suggested that ... 

Clearly, care must be exercised to ensure that dietary manipulation and supplementation do not produce oral loads able to swamp the body s defenses. For the reasons outlined above, a decision tree has been developed to assist in the risk assessment of botanical products. ... 

An updated decision tree flow diagram summarizing some of the steps required to assess safety of a major human drug metabolite is provided (Fig. 1.33). 

As in every safety study, the solution of heat accumulation problems can be undertaken by applying the two commonly used principles of simplification and worst-case approach, as described in Section 3.4.1. A typical procedure following these principles is illustrated with the example of a decision tree for the assessment of the risks linked with thermal confinement (Figure 13.7). 

Figure 13.7 Decision tree for the assessment of thermal confinement situations.

Given the tiered system, evidently, any step in the exposure and effects assessment can be considered in a deterministic or probabilistic way. This does affect the outcomes of the risk assessment, but it does not influence the choice of extrapolation methods as guided by the decision tree itself. 

With 3 tiers for both exposure and effects assessment, a decision tree can be designed as outlined in Figure 2.8 and described below. In the decision tree, the... 

Bindslev-Jensen, C., Sten, E., Earl, L., Crevel, R. W. R., Bindslev-Jensen, U., Hansen, T. K., Stahl Skov, R, and Poulsen, L. K. 2003. Assessment of the potential allergenicity of ice structuring protein type m HPLC 12 using the FAOAVHO 2001 decision tree for novel foods. Food Chem Toxicol 41(l) 81-87. 

Use the analysis of the scientific and practical state of the art to derive an applicable and comparable conceptual framework for human and ecological risk assessment of mixtures, including a practical decision tree and guidance (Section 5.4). 

FIGURE 21.2 Decision tree for thinking about ways to assess sex differences during the development of medical products. [Modified from Gender studies in product development Scientific issues and approaches. Executive summary. U.S. FDA, 1999. (Internet at http / / wwrwr.fda.gov/womens/ExecLitive.html).]... 

All scientific efforts are reviewed by an independent experts panel of academic dermatologists, toxicologists, and environmental scientists. The experts panel uses a decision tree approach to assessing the dermal, systemic, and environmental endpoints. Conclusions of the expert panel on safe use, drawn from critical evaluation of all available hazard data, and exposure information provided by industry, form the basis for standards issued by the International Fragrance Association. 

Shoreline assessment and countermeasures Disposal options Scenarios Decision trees Scenarios Exercises... 

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