Decipher

Flowever, if only the Darling-Deimison conplmg is important for the conpled stretches, what is its importance telling ns about the internal molecnlar motion It turns out that the right kind of analysis of the spectroscopic fitting Flamiltonian reveals a vast amonnt about the dynamics of the molecnle it allows ns to decipher the story encoded in the spectrum of what the molecule is really doing in its internal motion. We will approach this spectral cryptology from two complementary directions ... 

The following example illustrates the sort of deciphering that is associated with... 

Bowie, J.U. Deciphering the message in protein sequences tolerance to amino acid substitutions. Science 247 1306-1310, 1990. 

The statistical analysis in WASH-1400 suffers from a spectrum of problems, l angmg rom lack of data on which to base input distributions to the invention and the u.se of wrong statistical methods. Even when correct, the analysis is often presented in. so murky a way as to be [Pg.5]

What is the amino acid sequence of the fusion protein Where is the junction between /3-galactosidase and the sequence encoded by the insert (Consult the genetic code table on the inside front cover to decipher the amino acid sequence.)... 

Deciphering the code. The language of computational chemistry is littered with acronyms, what do these abbreviations stand for in terms of underlying assumptions and approximations ... 

The process of vibration analysis requires gathering complex machine data and deciphering it. As opposed to the simple theoretical vibration curves shown in Figures 43.1 and 43.2, the profile for a piece of equipment is extremely complex. This is tme because there are usually many sources of vibration. Each source generates its own curve, but these are essentially added together and displayed as a composite profile. These profiles can be displayed in two formats time-domain and frequency-domain. 

Three processes take place in deciphering the genetic information of DNA ... 

One of the m jor attractions in the metal-atom synthesis of dimer and cluster species is the ability to isolate highly unsaturated species, M Lm, that may then be considered to be models for chemisorption of the ligand, L, on either a bare, or a supported, metal surface (,100). It is quite informative to compare the spectral properties of these finite cluster-complexes to those of the corresponding, adsorbed surface-layers (100), in an effort to test localized-bonding aspects of chemisorption, and for deciphering UPS data and vibrational-energy-loss data for the chemisorbed state. At times, the similarities are quite striking. 

Many important erosion-related phenomena are episodic and infrequent, such as flash floods, landslides, and glaciations, while others such as orogenesis and soil formation involve time scales that exceed those of major climate fluctuations. In either case, the time scale of human existence is too short to make adequate observations. Consequently, it is difficult to directly estimate the rates or characterize the effects of such phenomena on erosion products. The key to understanding weathering and erosion, on a continental scale, is to decipher the relationship between landforms, the processes that produce them, and the chemistry and discharge of river-borne materials. 

Poor pharmacokinetics and toxicity are important causes of costly late-stage failures in drug development. It is generally recognized that, in addition to optimized potency and specificity, chemical libraries should also possess favorable ADME/Tox and druglike properties [77-80]. Assessment of druglike character is an attempt to decipher molecular features that are likely to lead to a successful in vivo and, ultimately, clinical candidate [81-83]. Many of these properties can be predicted before molecules are synthesized, purchased, or even tested in order to improve overall lead and library quality. 

The cell must possess the machinery necessary to translate information accurately and efficiently from the nucleotide sequence of an mRNA into the sequence of amino acids of the corresponding specific protein. Clarification of our understanding of this process, which is termed translation, awaited deciphering of the genetic code. It was realized early that mRNA molecules themselves have no affinity for amino acids and, therefore, that the translation of the information in the mRNA nucleotide sequence into the amino acid sequence of a protein requires an intermediate adapter molecule. This adapter molecule must recognize a specific nucleotide sequence on the one hand as well as a specific amino acid on the other. With such an adapter molecule, the cell can direct a specific amino acid into the proper sequential position of a protein during its synthesis as dictated by the nucleotide sequence of the specific mRNA. In fact, the functional groups of the amino acids do not themselves actually come into contact with the mRNA template. 

It is now known that each codon consists of a sequence of three nucleotides ie, it is a triplet code (see Table 38—1). The deciphering of the genetic code depended heavily on the chemical synthesis of nucleotide polymers, particularly triplets in repeated sequence. 

An interdisciplinary program to generate the information and technical tools needed to decipher the molecular anatomy of the cancer cell.)... 

In deciphering the role of the different NTs, or more precisely their antagonists, in the antischizophrenic action of neuroleptic drugs it must be remembered that published binding data and calculated dissociation constants vary considerably, which, of course, affects correlation coefficients made with clinical activity. Factors to bear in mind are ... 

Zwank L, M Berg, M Eisner, TC Schmidt, RP Schwarzenbach, SB Haderlien (2005) New evaluation scheme for two-dimensional isotope analysis to decipher biodegradation processes application to groundwater contamination by MTBE. Environ Sci Technol 39 1018-1029. 

Elia, V, Napoli, E. and Germano, R. (2007) The Memory of Water an almost deciphered enigma. Dissipative structures in extremely dilute aqueous solutions. Homeopathy, 96, 163-169. 

---