Danshen

Capsicum Celery Chamomile Clove Danshen Devil s claw ... 

NMR, UV and IR spectroscopies are routinely used for the characterization of the majority of reviewed systems and the reader is referred to the individual references for this information. The special cases of structure elucidation of a secondary metabolite of the Chinese drug Danshen Salvia miltiorrhiza Bunge) by... 

Danshen Inhibition of platelet Increased INR Fresh frozen... 

Danshen, the dried root and rhizome of S. miltiorrhizae (Fig. 2), is another Chinese botanical product used for its ability to alleviate menstrual irregularities, as well as for its vasodilative and hypotensive functions in a variety of cardiovascular conditions (8). The botanical product had also been shown to inhibit platelet aggregation in vitro (9). Danshen is widely available in different preparations for oral consumption, with usual dose range of 9 to 15 g per decoction. In addition, its increasing popularity is reflected by its availability even in Chinese cigarettes (10). 

Clinicians from Hong Kong reported a case of potential danshen-warfarin interaction in a 48-year-old female with a history of rheumatic heart disease, atrial fibrillation, and mitral stenosis (11). The patient underwent successful transvenous mitral valvuloplasty for management of her medical conditions, and was discharged with 1 mg warfarin, as well as... 

Cheng TO. Warfarin danshen interaction. Ann Thorac Surg 1999 67 894. 

Yu CM, Chan JCN, Sanderson IE. Chinese herbs and warfarin potentiation by Danshen. J Intern Med 1997 241 337-339. 

Tam LS, Chan TYK, Leung WK, Critchley JAJH. Warfarin interactions with Chinese traditional medicines danshen and methyl salicylate medicated oil. 

Lo ACT, Chan K, Yeung JHK, Woo KS. The effects of danshen Salvia miltior-rhiza) on pharmacokinetics and dynamics of warfarin in rats. Eur J Drug Metab Pharmacokinet 1992 17 257-262. 

Do not take or discontinue any other medication, including salicylates (e.g., aspirin and topical analgesics), other over-the-counter medications, and botanical (herbal) products (e.g., bromelains, coenzyme Qio, danshen, dong quai, garlic. Ginkgo biloba, ginseng, and St. John s wort ) except on advice of... 

Warfarin Danshen (Salvia miltiorrhiza) Increased INR, prolonged PT/PTT Danshen decreases elimination of warfarin... 

Although not commonly used in the U.S., danshen (the root of Salvia miltiorrhiza), also known as tan seng, is a very popular herb recommended in Chinese medicine for various cardiovascular diseases. The pharmacological effects of danshen have been described primarily in vitro and also in animals and include the following ... 

The available evidence contraindicates concurrent use of danshen and warfarin. 

Danshen Devil s claw Dong quai Papain Vitamin E... 

Potentiation of the effect of warfarin by danshen (the root of Salvia miltiorrhizd), a widely used traditional Chinese herbal medicine, particularly for cardiovascular complaints, has been described in a 62-year-old man with a mechanical mitral valve prosthesis (159). 

Salvia miitiorrhiza (danshen) Lamiaceae (mint) Bearberry Arctostaphylos uva-ursi... 

Zingiber officinale (ginger) Rosaceae Danshen Salvia miitiorrhiza... 

In China, the root of Salvia miltiorrhiza (danshen) has been used traditionally for the treatment of coronary diseases. 

A patient taking warfarin and who had taken a decoction of S. miltiorrhiza presented with a prolonged bleeding time and melena (12) and other cases have been reported (13). Pharmacodynamic and pharmacokinetic studies in rats have shown that danshen increases the absorption rate constant, AUC, and half-lives of both R- and 5-warfarin, and reduces their clearances and apparent volumes of distribution (14,15). 

Chan lY. Interaction between warfarin and danshen Salvia miltiorrhiza). Ann Pharmacother 2001 35(4) 501. ... 

Chan K, Lo AC, Yeung JH, Woo KS. The effects of Danshen Salvia miltiorrhiza) on warfarin pharmacodynamics and pharmacokinetics of warfarin enantiomers in rats. J Pharm Pharmacol 1995 47(5) 402-6. 

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