Theonella cupola

Oriamide (441), a cytotoxic peptide containing the unusual amino acid, 4-propenoyl-2-tyrosylthiazole, was isolated from a Theonella sp. from South Africa [367]. Theonella cupola from Indonesia and from... 

A Psammocinia sp. (Fig. 3.17) sponge from Papua New Guinea has yielded the potent cytotoxic cyclocinamide A (1026) (1063). The novel 6-chlorotryptophan derivatives, microsclerodermins C (1027) and D (1028), were characterized from a Philippines Theonella sp. sponge (1064). The related dehydromicrosclerodermins C (1029) and D (1030) are found in the sponge Theonella cupola from Okinawa (1065). 

Erdogan I, Tanaka J, Higa T (2000) Two Cyclic Hexapeptides from the Marine Sponge Theonella cupola. FAB AD J Pharm Sci 25 7... 

A new cyclic heptapeptide cupolamide A (55) was isolated from two samples of the sponge Theonella cupola collected in Indonesia and Okinawa [49]. Three of the aminoacid residues, fram,-4-hydroxyproline, homoarginine and 2,4-diaminobutanoic acid are of uncommon occurrence in particular the hydroxy-proline is a constituent of collagen and occasionally has been found in terrestrial biota [50] and in marine... 

C11H14CIN5O3 299.716 Isol. from marine sponges Theonella sp., Trachycladus laevispirulifer and Theonella cupola. Cytotoxic and immunosuppressive agent. May have activity against HIV. 

Heptapeptide Cupolamide A Theonella cupola Indonesia Bennington etal., 1997... 

Bonnington, LS., Tanaka. J., Higa, T, Kimura, J., Yoshimura, Y., Nakao, Y, Yoshida, WY, and Scheuer, P.J. (1997) Cupolamide A a cytotoxic cychc heptapeptide from two samples of the sponge Theonella cupola. J. Org. Chem., 62, 7765—7767. 

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