Cytarabine Ara

Dexa-BEAM dexamethasone/ carmustine (BCNU)/ etoposide (VP-16)/ cytarabine (Ara-C)/ melphalan Dexamethasone 8 mg PO Q8H days 1 -10 BCNU 60 mg/M2 IV day 2 VP-16 75 mg/M2 IV days 4-7 Ara-C 100 mg/M2 IVQ12H days 4-7 Melphalan 20 mg/M2 IV day 3 REF Pfreundschuh etal. J Clin Oncol 1994 12 580-586 PREMEDICATIONS 1. Kytril 1 mg PO/IV 30 minutes before and 12 hours after chemotherapy on days 2 and 3 2. Compazine 10 mg PO/IV 30 minutes before chemotherapy on days 4-7 OTHER MEDICATIONS 1. Give non-cisplatin delayed emesis prophylaxis Repeat every 28 days Carmustine—maximum total dose is 1440 mg/M2 causes delayed myelosuppression... 

Cytarabine (ara-C) is an S phase-specific antimetabolite that is converted by deoxycytidine kinase to the 5 -mononucleotide (ara-CMP). Ara-CMP is further metabolized to the diphosphate and triphosphate metabolites, and the ara-CTP triphosphate is felt to be the main cytotoxic... 

Clofarabine (Clolar) Cytarabine [ARA-C] (Cytosar-U) Cytarabine Liposome (DepoCyt) Floxuridine (FUDR) Fludarabine Phosphate (Flamp, Fludara)... 

Cytarabine (ara-C) is an arabinose analog of cytosine. Cytarabine was originally isolated from sponges, but is now produced synthetically. Ara-C is phosphorylated to its active triphosphate form (ara-CTP) within tumor cells. Ara-CTP inhibits DNA polymerase, an enzyme responsible for strand elongation. It is also incorporated directly into DNA, where it inhibits the replication of DNA and acts as a chain terminator to prevent DNA elongation. Activation of ara-C is opposed by deaminase enzymes, particularly cytidine deaminase, which degrades ara-C to an inactive form, ara-U. " " ... 

Cytarabine (ara-C cytosine arabinoside Cytosar U) ANLL ALL lymphomatous meningitis NHL MDS High-dose ara-C (HDAC) Liposomal cytarabine (Depocyt) for intrathecal use for lymphomatous meningitis... 

In some preparative regimens, the only drug given is cyclophosphamide, a drug with both immunosuppressive and cytotoxic effects. Because of the inadequate antitumor activity of cyclophosphamide in some types of cancers, other drugs are often added. Examples of drugs that often are included in preparative regimens are cytarabine (ara-C), busulfan, thiotepa, etoposide (VP-16), carboplatin, cisplatin, carmustine (BCNU), melphalan, and ifosfamide. ... 

The pyrimidine antimetabolite cytarabine (Ara-C) is commonly used in drug regimens for the acute leukemias. Cytarabine is dose-limited by hematotoxicity. Cerebellar dysfunction may also occur with Ara-C, especially if the drug is used at high doses. The answer is (B). 

Cytarabine (Ara-C) S-phase-specific Metabolized to ara-CTP, which is incorporated into DNA. Acts as a chain terminator and inhibits DNA polymerase. ... 

Preliminary studies with azauridine suggest that this material was effective for the treatment of herpes simplex and zoster infections of the human eye (69). Rabbits infected with vaccinia virus vaccine were com-pletely protected from pustule formation and erythema by 2-3 grams of compound injected IV (70). This material apparently has a low order of toxicity. 5-Bromo-2-deoxyuridine was found to inhibit a new virus, equine herpes 3, in rabbit kidney cells as well as pseudorabies, a DMA. virus, whereas vesicular stomatitis, an RNA virus, was resistant (71). A large number of nucleosides have been synthesized and tested in various systems for antiviral activity. 1-p-D-Arabinofuranosylcytosine (cytarabine ara-C) blocked DNA synthesis of herpes-infected cells (72) while a number of structurally related compounds showed some antiviral activity, although less than the parent compound (73,74,75,76). It is still too early to determine the ultimate value of these newer agents as "antiviral" drugs. 

Cytarabine(Ara-C, Cytosar-U) Aracytin, Cytarbel, Alexan, Crfptotethya crypta Sponge Antileukemic Cytostatic 1969... 

The antiviral action of 5-iododeox5oiridine (lUdR) (4.9) has already been described in Section 4.0. It is widely prescribed for herpetic infections of the conjimctiva. Cytarabine ( Ara C ) (4./0), more selective, is used for severe generalized herpes in man (see Section 4.0). Vidarabine ( Ara A ) (4.JJ), a newer drug, has given useful clinical results in viral pneumonia and herpetic encephalitis (Section 4.0). The action of all these substances is to block stages in the synthesis of viral nucleic acids. 

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