Rabbit kidney

Khirobadi, B.S., Fahy, G.M., Saur, J., Meryman, H.T. (1993). Perfusion of rabbit kidneys with 8 molar cryoprotectant (V52). Cryobiol. 30,611-612 (abstract). 

In further experiments to determine the rate of PIP2 hydrolysis in these rabbit kidney slices, radiolabel was... 

In recent studies on perfused rats hearts (Veitch et al., 1992), it was found that differences in the sensitivity of complexes 1-lV to ischaemic damage were dependent upon the duration of ischaemia and the presence of oxygen. The demonstration that complex 1 is a major defective site dependent upon isolation of mitochondria from homogenates of the tissue by in vitro methods seemed important to us. We therefore decided to attempt to make noninvasive measurements of mitochondrial function soon after reperfusion in transplanted rabbit kidneys by surface fluorescence (for mitochondrial NADH levels) and near infra-red spectroscopy (NIRS) for the redox state of cytaas. 

CotteriU, L.A., Gower, J.D., FuUer, B.J. and Green, C.J. (1989b). Oxidative stress during hypothermic storage of rabbit kidneys possible mechanisms by which calcium mediates free radical damage. Cryolett. 10, 119-126. 

Gower, J., Healing, G. and Green, C.J. (1989c). Measurement by HPLC of desferrioxamine-avaUable iron in rabbit kidneys to assess the effect of ischaemia on the distribution of iron within the total pool. Free Rad. Res. Commun. 5, 291-299. 

Gower, J.D., Ambrose, I.J., Manek, S., Bright, P.S., Dobbin, P.S., Hider, R.C., Goddard, J.G., Thomiley, M.S. and Green, C.J. (1993). The effect of a synthetic hexadentate iron chelator (CP130) and desferrioxamine on rabbit kidneys exposed to cold and warm ischaemia. Agents Actions 40, 96-105. 

Green, C.J., Healing, G., Lunec, J., FuUer, B.J. and Simpkin, S. (1986a). Evidence of free radical-induced damage in rabbit kidneys after simple hypothermic preservation and autotransplantation. Transplantation 41, 161-165. 

Bertran, J., et al. Expression of Na(+)-independent amino acid transport in Xenopus laevis oocytes by injection of rabbit kidney cortex mRNA. Biochem.J. 1992, 283, 717-723. 

Sawamura A, Kusunose E, Satouchi K, et al. Catalytic properties of rabbit kidney fatty acid omega-hydroxylase cytochrome P-450ka2 (CYP4A7). Biochim Biophys Acta 1993 1168(1 ) 30-36. 

Renal cell lines have been utilized to a limited extent for evaluation nephrotoxins. A rabbit kidney cell line (LLC-RKi) has been utilized for evaluating nephrotoxic antibiotics (Viano et al., 1983 Hottendorf et al., 1987 Williams et al., 1988). LLC-PKi cells have by far been the most widely employed cell line for studying drug-induced nephrotoxicity, specifically in the evaluation of aminoglycoside antibiotics (Hori et al., 1984 Schwertz et al., 1986 Williams et al., 1986b Holohan et al.,... 

Chung, S.D., Alavi, N., Livingston, D., Hiller, S. and Taub, M. (1982). Characterization of primary rabbit kidney cultures that express proximal tubule functions in a hormonally defined medium. J Cell Biol. 95 118-126. 

Cross, R.J. and Taggart, J.L. (1950). Renal tubular transport Accumlation ofp-aminohippurate by rabbit kidney slices. Amer. J. Physiol. 161 181-190. 

Ford, S.M., Bennett, D., Laska, D.A., Tay, L.K. and Williams, P.D. (1987). Biochemical comparison of fresh kidney homogenates, rabbit primary proximal tubule cultures (RPT), and a rabbit kidney epithelial cell line (LLC-RIG). FASEB J., April, 1987. 

Heidrich, H.G. and Dew, M.E. (1977). Homogeneous cell populations from rabbit kidney cortex. J. Cell Biol. 74 780-788. 

Sina, J.E, Bean, C.L., Noble, C. and Bradley, M.O. (1985). An in vitro nephrotoxicity assay utilizing proximal tubule suspensions from rabbit kidney. In In Vitro Toxicology, Vol 3. Mary Ann Liebert, New York, pp. 683-693. 

Tay, L.K., Bregman, D.L., Maters, B.G. and Williams, RD. (1988). Effects of A.s-diaminedi-chloroplatinum (I) on rabbit kidney in vivo and on rabbit renal proximal tubule cells in culture. Cancer Res. 48 2538-2543. 

Viano, I., Eandi, M. and Santiano, M. (1983). Toxic effects of some antibiotics on rabbit kidney cells. Int. J. Tiss. Reac. 2 11-186. 

Weinberg, J.M. (1985). Oxygen deprivation-induced injury to isolated rabbit kidney tubules. J. Clin. Invest. 76 1193-2108. 

Williams, P.D., Hitchcock, M.J.M. and Hottendorf, G.H. (1985). Effects of cephalosporins on organic ion transport in renal membrane vesicles from rat and rabbit kidney cortex. Res. Comm. Chem. Pathol. Pharmacol. 47(3) 357-371. 

Yang, I.S., Goldinger, J.M., Flong, S.K. and Taub, M. (1988). Preparation of basolateral membranes that transport p-aminohippurate from primary cultures of rabbit kidney proximal tubule cells. J. Cell. Physicol. 135 481-487. 

Anamura S, Dohi T, Shirakawa M, et al. 1988. Effects of phenolic dental medicaments on prostaglandin synthesis by microsomes of bovine tooth pulp and rabbit kidney medulla. Arch Oral Biol 33 355-360. 

Preliminary information useful in prodrug design has been obtained with amino acids attached to model aromatic amines. Thus, N-(naphthalen-2-yl) amides of amino acids (6.1, R=side chain of amino acid, R =H) proved to be of interest as test compounds to monitor peptidase activity such as ami-nopeptidase M (membrane alanyl aminopeptidase, microsomal aminopepti-dase, EC 3.4.11.2) [16][17], In the presence of purified rabbit kidney aminopeptidase M or human cerebrospinal fluid (CSF) aminopeptidase activity, the rate of hydrolysis decreased in the order Ala-> Leu->Arg->Glu-2-naphthyl-amide. Ala-2-naphthylamide, in particular, proved to be a good test compound, as its rate of hydrolysis was influenced by experimental conditions (preparation, inhibitors, etc.), as was the hydrolysis of a number of low-molecular-weight opioid peptides and circulating vasoactive peptides. 

Bailie MB, Smith JH, Newton JF, et al. 1984. Mechanism of chloroform nephrotoxicity. IV. Phenobarbital potentiation of in vitro chloroform metabolism and toxicity in rabbit kidneys. Toxicol Appl Pharmacol 74 285-292. 

Foulkes EC, Blanck S. 1984. The selective action of nickel on tubule function in rabbit kidneys. Toxicology 33 245-259. 

Medium Vitamin B[Z content (5 50 micrograms/100 grams). Clam, crab, egg yolk, heart (beef, chicken, rabbit), kidney (rabbit), liver (chicken, rabbit), oysters, sardine, salmon. 

Fig. 2. Change of relative band absorption 1110 cm-1 with time under effect of organism (9) and model media 1 0.01% proteinase solution, 2 chymotrypsin solution, 3 0.01% trypsin solution, 4 extract of rabbit kidneys, 5 extract of rabbit muscles, 6 extract of rabbit liver, 7 Ringer-Lock solution, 8 saline...

Fig. 4. Dependence of the effective crosslinking density of cured adhesive KL-3 on time for different media 1 proteinase solution, 2 extract of rabbit kidneys, 3 extract of rabbit liver, 4 extract of rabbit muscles, 5 Ringer-Lock solution, 6 saline, 7 animal organism...

Fructose diphosphatase has also been purified from acetone powders of rabbit kidney (63) by acid precipitation, ammonium sulfate precipitation, heating at pH 4.5, and chromatography on phosphocellulose, and sulfoethyl Sephadex. This preparation, which was homogeneous in gel electrophoresis, was employed for the immunological studies described earlier. 

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