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ARA-C cytarabine

ANC absolute neutrophil count ANLL acute nonlymphocytic leukemia ara-C cytarabine... [Pg.2325]

Ara-C, cytarabine ASP, asparaginase CALGB, Cancer and Leukemia Croup B CNS, centrai nervous system CTX, cyciophosphamide DEX, dexamethasone DNR, daunorubicin DOX, doxorubicin iT, intrathecai /y p mercaptopurine MTX, methotrexate PRED, prednisone TC, thioguanine VCR, vincristine. [Pg.2492]

P-D-Arabinofuranosylcytosine [147-94-4] (ara-C, 16), C H N O, reportedly has had significant therapeutic effects in patients with localized herpes zoster, herpes eye infections, and herpes encephaUtis (33), although several negative results have also been reported (34) (Fig. 2). Ara-C, also known as cytarabine, is quite toxic and is only recommended for very severe viral infections. It is rapidly deaminated in humans to the relatively inactive ara-U Ara-C is converted in the cell to the 5 -monophosphate by deoxycytidine kinase, followed by formation of the corresponding di- and triphosphate. The triphosphate has been shown to inhibit DNA polymerase. [Pg.305]

Cylarabine (Ara-C cytosine arabinoside Cytosar U)d ANLL ALL Lymphomatous meningitis NHL MDS High-dose ara-C (HDAC) liposomal cytarabine (Depocyt) for intrathecal use for lymphomatous meningitis... [Pg.1408]

Dexa-BEAM dexamethasone/ carmustine (BCNU)/ etoposide (VP-16)/ cytarabine (Ara-C)/ melphalan Dexamethasone 8 mg PO Q8H days 1 -10 BCNU 60 mg/M2 IV day 2 VP-16 75 mg/M2 IV days 4-7 Ara-C 100 mg/M2 IVQ12H days 4-7 Melphalan 20 mg/M2 IV day 3 REF Pfreundschuh etal. J Clin Oncol 1994 12 580-586 PREMEDICATIONS 1. Kytril 1 mg PO/IV 30 minutes before and 12 hours after chemotherapy on days 2 and 3 2. Compazine 10 mg PO/IV 30 minutes before chemotherapy on days 4-7 OTHER MEDICATIONS 1. Give non-cisplatin delayed emesis prophylaxis Repeat every 28 days Carmustine—maximum total dose is 1440 mg/M2 causes delayed myelosuppression... [Pg.98]

Cytarabine is an effective antimetabolite in treating leukemia. Like other pyrimidine antimetabolites, cytarabine must be activated by initially transforming into the corresponding nucleotide. The active form of the drag is cytarabine triphosphate. Cytarabine is used for all types of leukemia. Synonyms of this drug are cytosine, arabinoside, and ara-C. [Pg.395]

Cytarabine (cytosine arabinoside, ara-C, Cytosar-U) is an analogue of the pyrimidine nucleosides cytidine and deoxycytidine. It is one of the most active agents available for the treatment of acute myelogenous leukemia. Cytarabine kills cells in the S-phase of the cycle by competitively inhibiting DNA polymerase. The drug must... [Pg.645]

Fig. 1. Outline of treatment strategy applied in the ALL-Berlin-Frankfurt-Munster (BFM) 95 study (1995-2000). Patients were assigned to standard-risk (SR), intermediate-risk (MR) and high-risk (HR) subgroups. Elements containing 6-mercaptopurine (6-MP) or 6-thioguanine (6-TG) are indicated in grey. Abbreviations PRED-GR, prednisone good response PRED-PR, prednisone poor response DEXA, dexamethasone VCR, vincristine DNR, daunorubicin HD-MTX, high-dose methotrexate LD-ARA-C, low-dose cytarabine SCT, stem cell transplantation. Fig. 1. Outline of treatment strategy applied in the ALL-Berlin-Frankfurt-Munster (BFM) 95 study (1995-2000). Patients were assigned to standard-risk (SR), intermediate-risk (MR) and high-risk (HR) subgroups. Elements containing 6-mercaptopurine (6-MP) or 6-thioguanine (6-TG) are indicated in grey. Abbreviations PRED-GR, prednisone good response PRED-PR, prednisone poor response DEXA, dexamethasone VCR, vincristine DNR, daunorubicin HD-MTX, high-dose methotrexate LD-ARA-C, low-dose cytarabine SCT, stem cell transplantation.
Cytarabine (ara-C) is an S phase-specific antimetabolite that is converted by deoxycytidine kinase to the 5 -mononucleotide (ara-CMP). Ara-CMP is further metabolized to the diphosphate and triphosphate metabolites, and the ara-CTP triphosphate is felt to be the main cytotoxic... [Pg.1173]

Clofarabine (Clolar) Cytarabine [ARA-C] (Cytosar-U) Cytarabine Liposome (DepoCyt) Floxuridine (FUDR) Fludarabine Phosphate (Flamp, Fludara)... [Pg.37]

See other pages where ARA-C cytarabine is mentioned: [Pg.1302]    [Pg.138]    [Pg.157]    [Pg.175]    [Pg.40]    [Pg.36]    [Pg.1302]    [Pg.138]    [Pg.157]    [Pg.175]    [Pg.40]    [Pg.36]    [Pg.72]    [Pg.147]    [Pg.151]    [Pg.151]    [Pg.305]    [Pg.1285]    [Pg.80]    [Pg.254]    [Pg.80]    [Pg.87]    [Pg.87]    [Pg.89]    [Pg.105]    [Pg.112]    [Pg.38]    [Pg.122]    [Pg.721]    [Pg.72]    [Pg.639]    [Pg.236]    [Pg.451]    [Pg.552]    [Pg.1163]    [Pg.160]    [Pg.122]    [Pg.99]   
See also in sourсe #XX -- [ Pg.122 ]

See also in sourсe #XX -- [ Pg.122 ]

See also in sourсe #XX -- [ Pg.122 ]



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