Cutaneous pathology

Seasonal changes affect the condition of normal skin and may trigger various cutaneous disorders.28,29 In common dermatitis, a decline in barrier function often parallels the increased severity of clinical symptomatology. All these conditions tend to worsen during the winter season when humidity is low.30,31 Abundant indirect evidence indicates that decreased humidity precipitates these disorders, whereas, in contrast, increased skin hydration appears to ameliorate these conditions. The mechanisms by which alterations in relative humidity might influence cutaneous function and induce cutaneous pathology are poorly understood. 

The free radical hypothesis of UV-light-induced cutaneous pathology is supported by these studies - antioxidant levels decrease on irradiation, as would be expected with a free radical load, lipid peroxidation increases tremendously, and supplementation with a-tocopherol prevents this damage. Future studies are necessary to clarify the relationships between cutaneous antioxidants during... 

Psoriasis is an inflammatory skin disease characterized by red, scaly, raised plaques. Usually, the psoriasis lesions are several centimeters in diameter and separated by normal-appearing skin [239, 240]. Psoriasis involves a chronic cutaneous pathologic process, driven by interactions between infiltrating leukocytes (Tcells, dendritic cells, macrophages, neutrophils), cytokines, chemokines and keratinocytes, the cells from the epidermis. The disease is initiated or exacerbated by infections, physical and/or emotional stress, antigenic stimuli and various medications (e.g., lithium, P-block-ers [241, 243]). Psoriatic plaques can revert back to symptomless skin spontaneously or after treatment vdth selective immune-targeted agents [239, 240, 242-244]. 

Among the main topics that may be interesting in our cutaneous pathology framework, we... 

Barksdale SK, HaUahan CW, Kerr GS, et al. Cutaneous pathology in Wegener s granulomatosis. A clinicopathologic study of 75 biopsies in 46 patients. Am J Surg Pathol 1995 19(2) 161-172. 

Brockow K, Akin C, Huber M. Metcalfe D Assessment of the extent of cutaneous involvement in children and adults with mastocytosis relationship to symptomatology, tryptase levels, and bone marrow pathology J Am Acad Dermatol 2003 48 508-516. 

The neuropathological analysis of HIV-associated neuropathies should include the different central and peripheral nervous system structures associated with sensory pathways, including spinal cord, dorsal root ganglia (DRG), peripheral nerve, and cutaneous nerve fibers (Pardo et al. 2001) (Fig. 4.1). The majority of studies have focused on the evaluation of the peripheral nerve, often from sural nerve biopsies and the DRG. Few studies have examined the pathology of sensory pathways in the... 

Papirmeister, B., Gross, C., Petrali, J., Hixson, C. (1984). Pathology produced by sulfur mustard in human skin grafts on athymic nude mice, I Gross and light microscopic changes. J. Toxicol. Cutan. Ocul. Toxicol. 3 371-91. 

Graham, J.S., Reid, F.M. et al. (2000). A cutaneous full-thickness liquid sulfur mustard hum model in weanling swine clinical pathology and urinary excretion of thiodiglycol. J. Appl. Toxicol. 20 (Suppl. 1) S161-72. 

DTncan M, Souteyrand P, Bignon YJ, Fonck Y, Roger H. Hydantoin-induced cutaneous pseudolymphoma with clinical, pathologic, and immunologic aspects of Sezary syndrome. Arch Dermatol 1992 128(10) 1371. ... 

There are no significant pathologic changes with the infection. The most common problem is cutaneous irritation in the perianal... 

Shieh WJ, Guarner J, Paddock C, et al. The critical role of pathology in the investigation of bioterrorism-related cutaneous anthrax. Am J Pathol. 2003 163 1901-1910. 

Fernando SS, Johnson S, Bate J. Immunohistochemical analysis of cutaneous malignant melanoma comparison of SlOO protein, HMB-45 monoclonal antibody, and NKI/C3 monoclonal antibody. Pathology. 1994 26 16-19. 

Wick MR, Ritter JH, Lind AC, et al. The pathological distinction between deep penetrating dermatofibroma and dermatofibrosarcoma protuberans. Semin Cutan Med Surg. 1999 18 91-98. 

Mentzel T. Cutaneous perineurioma clinical and histological findings and differential diagnosis. Pathologe. 2003 24 207-213. 

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