Curcumin inhibitory effects

Dimethylhydrazine (DMFI)-induced rat colon carcinogenesis model was used for evaluation of the synergistic inhibitory effect between curcumin and catechin in light of ACF formation and tumor incidence. The results of this... 

Anuchapreeda S, Limtrakul P, Thanarattanakorn P, Sittipreechacharn S, Chanarat P. 2006a. Inhibitory effect of curcumin on WT1 gene expression in patient leukemic cells. Arch Pharm Res 29 80-87. 

Du B, Jiang L, Xia Q, Zhong L. 2006. Synergistic inhibitory effects of curcumin and 5-fluorouracil on the growth of the human colon cancer cell line HT-29. Chemotherapy 1 23-28. 

Khor TO, Keum YS, Lin W, Kim JH, Hu R, Shen G, Xu C, Gopalakrishnan A, Reddy B, Zheng X, Conney AH, Kong AN. 2006. Combined inhibitory effects of curcumin and phenethyl isothiocyanate on the growth of human PC-3 prostate xenografts in immunodeficient mice. Cancer Res 66 613-621. 

Wang YD, Hu Y, Sun CY. 2006b. [Inhibitory effect of curcumin on angiogenesis induced by brain derived neurotrophic factor from multiple myeloma cells]. Zhong-guo Shi Yan Xue Ye Xue Za Zhi 14 70-74. 

Zheng LD, Tong QS, Wu CH. 2002. Inhibitory effects of curcumin on apoptosis of human ovary cancer cell line A2780 and its molecular mechanism. Ai Zheng 21 1296-1300. 

Zheng L, Tong Q, Wu C. 2004. Growth-inhibitory effects of curcumin on ovary cancer cells and its mechanisms. J Huazhong Univ Sci Technolog Med Sci 24 55-58. 

Korutla, L. and Kumar, R., Inhibitory effect of curcumin on epidermal growth factor receptor kinase activity in A431 cells, Biochim. Biophys. Acta, 1224, 597, 1994. 

Lin, J.K. and Shih, C.A., Inhibitory effect of curcumin on xanthine dehydroge-nase/oxidase induced by TPA in NIH3T3 cells. Carcinogenesis, 15, 1717, 1994. 

Huang, M-T., Wang, Z.Y., Georgiadis, C.A., Laskin, J.D., and Conney, A.H., Inhibitory effects of curcumin on tumor initiation by benzo[a]pyrene and 7,12-dunethyl-benz[a]anthracene, Carcinogenesis, 13, 2183, 1992. 

Huang, M.-T., Smart, R.C., Wong, C.-Q., and Conney, A.H., Inhibitory effect of curcumin, chlorogenic acid, caffeic acid, and ferulic acid on tumor promotion in mouse skin by 12-0-tetradecanoylphorbol-13-acetate, Cancer Res., 48, 5941, 1988. 

Elattar, T.M. and Virji, A.S., The inhibitory effect of curcumin, genistein, quercetin and cisplatin on the growth of oral cancer cells in vitro, Anticancer Res., 20, 1733, 2000. 

Similarly, the phenolic antioxidants p-coumaric acid, ferulic acid, curcumin, and caffeic acid, which are found in coriander (as well as members of the Labiatae family, see below), inhibit the formation of 3-nitrotyrosine in vitro and may prevent lipid peroxidation in vivo [14, 15]. Caffeic acid and other hydroxycinnamic acids have also been found to exert an inhibitory effect on LDL oxidation, a known risk factor for CHD [16]. 

The effect of curcumin on apoptosis in multidmg-resistant cell lines has been reported. Piwocka et al. ° demonstrated that curcumin induced cell death in multidrag-resistant CEM(P-gp4) and LoVo(P-gp4) cells in a caspase-3-independent maimer. Mehta et al. also examined the antiproliferative effects of curcumin against multidrag-resistant (MDR) lines, which were found to be highly sensitive to curcumin. The growth-inhibitory effect of curcumin was time- and dose-dependent and was correlated with its inhibition of ornithine decarboxylase activity. Curcumin preferentially arrested cells in the G2/S phase of the cell cycle. 

Huang, M.T., Newmark, H.L., and Frenkel, K., Inhibitory effects of curcumin on tumorigenesis in mice, J. Cell Biochem. Suppl, 27, 26-34,1997. 

Xu, J., Fu, Y., and Chen, A., Activation of peroxisome proliferator-activated receptor-gamma contributes to the inhibitory effects of curcumin on rat hepatic stellate cell growth. Am. J. Physiol. Gastrointest Liver Physiol, 285 (1), G20-30, 2003. 

Verma, S. R, Salamone, E., and Goldin, B., Curcumin and genistein, plant natural products, show synergestic inhibitory effects on the growth of human breast cancer MCF-7 cells induced by estrogenic pesticides, Biochem. Biophys. Res. Commun.( 991) 233(3), 692-696. 

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