Curcumin growth inhibitory effect

Zheng L, Tong Q, Wu C. 2004. Growth-inhibitory effects of curcumin on ovary cancer cells and its mechanisms. J Huazhong Univ Sci Technolog Med Sci 24 55-58. 

The effect of curcumin on apoptosis in multidmg-resistant cell lines has been reported. Piwocka et al. ° demonstrated that curcumin induced cell death in multidrag-resistant CEM(P-gp4) and LoVo(P-gp4) cells in a caspase-3-independent maimer. Mehta et al. also examined the antiproliferative effects of curcumin against multidrag-resistant (MDR) lines, which were found to be highly sensitive to curcumin. The growth-inhibitory effect of curcumin was time- and dose-dependent and was correlated with its inhibition of ornithine decarboxylase activity. Curcumin preferentially arrested cells in the G2/S phase of the cell cycle. 

Du B, Jiang L, Xia Q, Zhong L. 2006. Synergistic inhibitory effects of curcumin and 5-fluorouracil on the growth of the human colon cancer cell line HT-29. Chemotherapy 1 23-28. 

Khor TO, Keum YS, Lin W, Kim JH, Hu R, Shen G, Xu C, Gopalakrishnan A, Reddy B, Zheng X, Conney AH, Kong AN. 2006. Combined inhibitory effects of curcumin and phenethyl isothiocyanate on the growth of human PC-3 prostate xenografts in immunodeficient mice. Cancer Res 66 613-621. 

Korutla, L. and Kumar, R., Inhibitory effect of curcumin on epidermal growth factor receptor kinase activity in A431 cells, Biochim. Biophys. Acta, 1224, 597, 1994. 

Elattar, T.M. and Virji, A.S., The inhibitory effect of curcumin, genistein, quercetin and cisplatin on the growth of oral cancer cells in vitro, Anticancer Res., 20, 1733, 2000. 

Xu, J., Fu, Y., and Chen, A., Activation of peroxisome proliferator-activated receptor-gamma contributes to the inhibitory effects of curcumin on rat hepatic stellate cell growth. Am. J. Physiol. Gastrointest Liver Physiol, 285 (1), G20-30, 2003. 

Verma, S. R, Salamone, E., and Goldin, B., Curcumin and genistein, plant natural products, show synergestic inhibitory effects on the growth of human breast cancer MCF-7 cells induced by estrogenic pesticides, Biochem. Biophys. Res. Commun.( 991) 233(3), 692-696. 

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