Cunninghamella blakesleeana

Absidia glauca, Cunninghamella blakesleeana, Cunninghamella sp., Fusarium solan f. sp. cucurbitae, and Rhizopogon sp. 

Xie, Z. Y., Huang, H.H. andZhong, D.F. (2005) Biotransformation of pantoprazole by the fungus Cunninghamella blakesleeana. Xenobiotica The Fate of Foreign Compounds in Biological Systems, 35, 461-411. 

Fig. (42). Biotransformation of germacrone by Cunninghamella blakesleeana (after [153]) and by Aspergillus niger (after [154])...

C. Bisbenzylisoquinolines and related alkaloids ( + )-tetrandrine (111) Cunninghamella blakesleeana... 

In addition to the transformations by rat liver enzymes discussed above, (R,5 )-laudanosine is metabolized by a variety of microorganisms to produce products that include the O-demethyl compound pseudocodamine (104) (101). Of over 60 microorganisms screened, Cunninghamella blakesleeana ATCC 8688a gave the highest isolable yield of 104 (44%). The structure of... 

Cunninghamella blakesleeana ATCC 9245 Cmninghamella blakesleeana NRRL 1369 Streptomyces rimosus ATCC 23955... 

Microbiological transformation of laudanosine by the micro-organism Cunninghamella blakesleeana is accomplished by selective demethylation, to give i/f-codamine (19).29 Isoquinoline alkaloids that can be selectively halogenated can readily be converted into hydroxy-compounds by lithiation of the bromo-... 

Bile acids have historically received much less attention than other steroids, for example the corticosteroids however, now that useful therapeutic effects are being observed from some bile acids, there is fresh interest in this area. A strain of Cunninghamella blakesleeana has been isolated that will IS -hy-droxylate lithocholic acid (80 equation 26) in 31% yield.Further reaction is possible to give 3a,lip,15p-trihydroxy-5P-cholanic acid (15%), 3a,15p,18a-trihydroxy-53-cholanic acid (4%) and 3a,lla,15p-trihydroxycholanic acid (9%). Taurolithocholic acid (81 equation 27) can be 7P-hydroxy-lated in virtually quantitative yield by Mortierella ramanniana. ... 

Secondary steroidal alcohols react in preference to primary allylic alcohols in biochemical oxidations usingJihizopus arrhizus and Helicostylum piriforme or Cunninghamella blakesleeana. However, the reaction is complicated by hydroxylations in positions 6 (with Rhizopus arrhizus) and 9 (with Helicostylum piriforme or Cunninghamella blakesleeana) [1059]. 

Desoxycorticosterone (4-pregnen-21-ol-3,20-dione) is converted into A -pregnene-lla,17ot-diol-3,20-dione by Aspergillus niger in 67% yield [1045] and to 7a-hydroxydesoxycorticosterone in 36% yield by Peziza sp. ETH,M.23 [1064], 17a-Hydroxydesoxycorticosterone is hydroxylated in the 11a position by Cunninghamella blakesleeana H-334 [1060, 1061] and in the 15 position hy Bacillus megaterium in 50% yield [1051] (equations 404 and 405). 

Microbiological hydroxylation of A -THC using Cunninghamella blakesleeana results in 6a - and/or 4 -hydroxylation some 7-hydroxylation occurs in combination with 4 -hydroxylation, ° in contrast to metabolism in dog lung when the major metabolites are 3 -hydroxy- and 4 -hydroxy-A -THC in addition to small amounts of 7-hydroxy, 6o -hydroxy-, and 6/3-hydroxy-A -THC." In liver tissue, the proportions of these metabolites are reversed. This less common C-4 side-chain... 

Venkateswerlu, G., Yorder, M. J., and Stotzky, G. (1989). Moiphological ultra-structural, and chemical changes induced in Cunninghamella blakesleeana by copper and cobalt. Appl. Microb. Biotechnol. 31, 204—210. 

Ibrahim 407) has reported a microbial transformation of emetine (1) into O-methylpsychotrine (4), which used Cunninghamella blakesleeana MR-198. The first synthesis of the alkaloid glucoside neoalangiside (48) has been achieved with the Aimi et al. 408). It started with the condensation of the brominated phenethylamine 196 with the tetra-O-acetyl derivative of secologanin (132) and proceeded through the intermediates 197 and 198. 

Diosgenin, recently isolated in high yield from the rhizomes of Costus speciosus, " is microbiologically hydroxylated by Cunninghamella blakesleeana to 7 -hydroxy-, 7/5,1 la-dihydroxy-, and 7/5,12/8-dihydroxy-diosgenin and oxidised by Mycobacterium phlei to mixtures of A" - and A -3-ketones. 

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