Plant homeodomain

Lysine methylation marks Monoamine oxidase inhibitor Plant homeodomain Posttranslational modification Protein lysine methyl transferase... 

The specific domains that recognize KMe have been described within several protein families the so-called "royal family" of Tudor, Agenet, chromo, PWWP, and MBT domains the plant homeodomain (PHD) the WD40 repeat protein—WDR5 and ankyrin repeats [37,38]. Given the rapid rate of progress in this area, the relatively low affinity of these interactions (Kd values typically 10-100 jjM), the wide variety of... 

Abbreviations CBP, CREB binding protein CREB, cAMP response element binding protein FAT, factor acetyltransferase HAT, histone acetyltransferase MEL, mixed lineage leukaemia protein MORE, MOZ related factor MOZ, monocytic leukaemia zinc finger protein PHD, plant homeodomain RTS, Rubinstein-Taybi syndrome, TIE, transcription intermediary factor... 

With regard to specificity, plant homeodomain (PHD) fingers constitute the most diverse class of histone binding modules. These modules recognize lysine in unmodified, mono-, di- and trimethylated states. Although not stmcturally related. 

Gozani, O. and Yang, W. (2007) The plant homeodomain finger of RAG2 recognizes histone H3 methylated at both lysine-4 and arginine-2. Proceedings of the National Academy of Sciences of the United States of America, 104, 18993-18998. 

Plant homeodomain (PHD) fingers recognize different methylation states of histone H3 Lys4 (H3K4). 

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