Coumarins angelica

Coumarins Angelica archangelica, Agrimonia eupatoria, Anethum... 

Nine coumarin compounds Coumarins Angelica gigas Analytical RPC DAD UV, MS 193... 

P. Flarmala, L. Botz, O. Sticher and R. Fliltunen, Two-dimensional planar chromatographic separation of a complex mixture of closely related coumarins from the genus Angelica, J. Planar Chromatogr. 3 515-520 (1990). 

The 2D chromatograms reveal additional components of the natural mixtures. They also give a map of the essential oil, which is helpful in the identification of the components by the position and the characteristic colours of the derivatives on the plate. A further, considerable improvement in the separation performance can be obtained by using overpressured layer chromatography (OPLC). Harmala et al. (70) used 2D OPLC for the separation of coumarins from the genus Angelica. Figure 10.15 shows the one-dimensional (a) and two-dimensional (b) OPLC separations of 16 coumarins. 

Decursinol (18) is a naturally occurring coumarin compound isolated from Angelica gigas (Umbelliferae). In recent studies, two important properties of this compound have been discovered, affecting neuropathology in AD. In one study, mice pretreated with decursinol were able to... 

The furanocoumarins xanthotoxin (77) and isopimpinellim (78) from roots of A. acutiloba displayed significant AChE inhibitory activity with IC50 values of 0.58 xM and 0.32 xM respectively." Prenylated coumarins itom. Angelica spp. had only weak activity, with decursinol (79) giving the highest activity (IC50 value 28 xM)." ... 

Kang SY, Lee KY, Sung SH, Park MJ, Kim YC, Coumarins isolated from Angelica gigas inhibit acetylcholinesterase Structure-activity relationships, f Nat Prod 64 683-685,2001. 

The lactones are the intramolecular esters of the corresponding hydroxy fatty acids. They contribute to the aroma of butter and various fruits. 15-Pentadeca-nolide is responsible for the musk-like odor of angelica root oil. Of the naturally occurring bicyclic lactones, phthalides are responsible for the odor of celery root oil, and coumarin for woodruff. 

In addition to the presence of natural coumarin derivatives, phytochemical analysis found that dong quai also contains ferulic acid and osthole as ingredients. Ferulic acid was reported to have antithrombotic activity (38). Similarly, study using the closely related Angelica pubescens also found osthole to be antithrombotic (39). These two chemical constituents exert their antithrombotic effects by interfering with different pathways responsible... 

Warfarin Dong quai (Angelica sinensis) Increased INR and widespread bruising Dong quai contains coumarins... 

PROP The constituents include d-a-terpineol, butyl dihydrophthalides, butyl tetrahydrophthalides, coumarin, aldehydes, acetic acid, and isovaleric acid. From steam distillation of fresh root of Ijevisticum officinale L. Koch syn. Angelica levisticum, Baillon (Fam. Vmbelliferae). Yellow to green to brown liquid strong odor and taste. D ... 

Decursinol is a major coumarin derived from the roots of Angelica gigas and has various pharmacological effects against inflammation, angiogenesis, nociceptive pain, and AD [206]. 

Twenty-one different coumarin-type Coumarins and furanocoumarins Peucedanum palustre and Angelica archangelica Analytical RPC based on computer-assisted optimization UV, MS 47... 

Coumarins bergapten, umbelliferone generally lower coumarin content than Angelicae and Imperatoriae radix Phtalide 3-butylidenephtalide (ligusticum-lacton)... 

Description More than 15 structurally similar furatiocoumarins (fes) and coumarins are identified compounds of Imperatoriae radix (1) and Angelicae radix (2). Levistici radix (3) differs from 1 and 2 by a generally lower coumarin content. Because of their structural similarity, fes are found as overlapping zones specifically in the R, range 0.5-0.65. In the table below, the known fes in the drug samples 1-3 are li.sted ... 

Inhibition of chemical carcinogen-induced neoplasia by coumarins and a-angelica lactone Cancer Res. 39 27A09. 

Coumarins isolated from fragrant angelica administered orally to rats in single doses of 25,50, or 100 mg/kg increased the duration of hypnosis induced by pentobarbital sodium. The 100 mg/kg dose also prolonged the latent period and shortened the duration of hypnosis induced by barbital sodium (Liu et al. 2006). 

Murphy, E.M. Nahar, L. Byres, M. Shoeh, M. Siakalima, M. Rahman, M.M. Gray, A.I. Sarker, S.D. Coumarins from the seeds of Angelica sylvestris (Apiaceae) and their distrihution within the genus Angelica. Biochem. Syst. Ecol. 2004, 32, 203-207. 

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