Cosolvents, pharmaceutical cosolvent solubilization

EINECS 249-793-7 2-Ethylhexyl 12-hydroxy octa-decanoate 2-Ethylhexyl 12-hydroxystearate Octa-decanoic acid, 12-hydroxy-, 2-ethylhexyl ester Wickenol 171. Emollient, nxiistunzer, pigment wetter/dispersant increases water vapor porosity of fatty components used in cosmetic and topical pharmaceutic preparations refattfng agent, counterirritant, cosolvent, solubilizer. CasChem. [Pg.454]

Uses Emollient, cosolvent, solubilizer for cosmetics, pharmaceutical topicals emulsifier, lubricant, antistat, defoamerfor metalworking, textiles, plastics, paper Manuf./Distrib. A8iE Connock http //WWW. connock. co. uk Trade Name Synonyms Ceraphyl 140-A [ISP Van Dyk S. Black http //www.sblack.com], Estalan-IDO [Lanaetex Prods.] Estol IDCO... [Pg.2225]

CAS 42131-28-2 EINECS/ELINCS 255-674-0 Synonyms 2-Hydroxypropanoic acid, isostearyl ester Isooctadecyl 2-hydroxypropanoate Definition Ester of isostearyl alcohol and lactic acid Empiricai C21H42O3 Formuia CH3CHOHCOOC18H37 Uses Emollient, substantivity agent, softener, slip agent, lubricant, cosolvent, solubilizer in cosmetics and pharmaceuticals Manuf./Distrib. ASiE Connock http //www. connock. co. uk Trade Name Synonyms Patlac IL [Am. Ingreds. http //www. americaningredients. com, R. I. T.A. http //www.ritacorp.com], Pelemol ISL [Phoenix http //www.phoenix-chem.com] Isostearyl myristate CAS 72576-81-9... [Pg.2280]

Uses Emollient, cosolvent, solubilizer tor cosmetic systems, topical pharmaceuticals, liq. makeup binder tor pressed powd. wetting agent tor iron oxides cleansing agent for emulsions... [Pg.232]

Uses Emollient, softener, gloss aid, lubricant for cosmetics, hair care, skin care, topical pharmaceuticals cosolvent, solubilizer In perfumes lubricant for metalworking and wire drawing pigment dispersant and binder in color cosmetics Features Nonoily... [Pg.982]

Uses Emollient, moisturizer, pigment wetting agent/dispersant, refatting agent, counterirritant, cosolvent, solubilizer in cosmetics, topical pharmaceuticals Features Increases water vapor porosity of fatty components Properties Gardner 2+ color sol. in acetone, castor, corn, and min, oil, chloroform, ethyl acetate, ethanol pour pt. 5 C acid no. 0.30 ref index 1456 Wickenol 535 [AIzo]... [Pg.1222]

Uses Emollient, cosolvent, solubilizer for cosmetics, pharmaceutical topicals ... [Pg.2167]

Uses Dispersant, emulsifier, wetting agent, cosolvent, solubilizer, thickener, emollient, opacifier, spreading agent in cosmetics, pharmaceuticals, foods, agric., plastics, other industries defoamer in food-contact paper/paperboard in resinous/ polymeric food-contact coatings in resin-bonded filters for food contact in food-contsct tsxtiiss... [Pg.2287]

Li, P, L. Zhao, and S. H. Yalkowsky (1999). Combined effect of cosolvent and cyclodextrin on solubilization of nonpolar drugs journal of pharmaceutical sciende harm. Sci., 88 1107-1111. [Pg.131]

Identification of pharmaceutically acceptable vehicles that afford sufficient solubilization while maximizing physiological compatibility for preclinical pharmacokinetic evaluation is critical. The most frequently used solubilization techniques include pH manipulation for ionizable compounds use of cosolvents such as PEG 400, ethanol, DMSO, and propylene glycol micellar solubilization with surfactants such as Tween 80 or SLS complexation with cylodextrins [40]. By using the solubilization techniques, the enhancement in solubility of poor water-soluble compounds can be significant compared to aqueous solubility and can facilitate the absorption of drug molecules in the gastrointestinal tract when delivered in solution form. [Pg.589]

Dimethylacetamide is used as a solvent in oral and injectable pharmaceutical formulations. It has been used as a cosolvent to solubilize poorly soluble drugs. The use of dimethylacetamide has also been investigated as a vehicle for the parenteral delivery of relatively small peptides. ... [Pg.253]

Urethane may be released to the environment in various waste streams from its production and use in the preparation and modification of amino resins, as a solubilizer and cosolvent for pesticides and fumigants, as an intermediate in the production of pharmaceuticals, as an antineoplastic agent, and as a reagent in biochemical research. If released to the atmosphere, urethane is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase urethane will be degraded in the atmosphere by reaction with photochemically produced hydroxyl radicals with an estimated half-life of 2.2 days. If released to soil, urethane is expected to have very high mobility. Volatilization from moist soil surfaces is not expected to occur. Biodegradation of urethane in soil may be important. If released into water, urethane is not expected to adsorb to suspended solids and sediment in the water column. Volatilization from water surfaces is not expected. The potential for bioconcentration in aquatic organisms is... [Pg.2803]

Polylan . [Ametchol AmercholEur( ] Oleyl linoleate, lanolin linoleate emollient, dispersant, conditKxwr, penetrant, lubricant cosolv dye solubilizer used in cosmetics and pharmaceuticals. [Pg.288]

On Route 1, the deficient solubility of a drag candidate is overcome by physical means ranging from solubilization by cosolvents to complex pharmaceutical-technological systems. This kind of problem-solving is handled in the realm of the pharmacist during formulation development, and is discussed in this chapter. [Pg.631]

Uses Cosolvent, coupling agent for org. compds. w/o emulsifier anti-stat, lubricant for syn. materials emulsifier, emollient for cosmetics, foods, pharmaceuticals solvent, dispersant, solubilizer, vehicle, pen-... [Pg.1128]

Uses Emulsifier, solubilizer for foods, cosmetics, household prods., industrial applies., coatings, household (polishes, cleaners), pharmaceuticals lubricanL antifog, antistat for PVC and other plastics antifog for food-pkg. films emulsifier for thermoplastics polymerization emulsifier in food pkg. emollient for skin care prods. lubricant, emulsifier in textile spin finishes cosolvent foods (crystallization retarder, dough improver)... [Pg.1356]

Toxicology LDLo (oral, rat) 8 g/kg mildly toxic by ing. primary skin irritant TSCA listed Hazardous Decomp. Prods. Heated to decomp., emits acrid smoke and irritating vapors Uses Binder, emollient, cosolvent, lubricant, refatting agent, skin softener, moisture retention aid for cosmetics, toiletries, hair care, skin care, sunscreens, soaps, topical pharmaceuticals lubricant for textile processing solubilizer for essential oils and lipophilic act. ingreds. defoamer in food-contact paper/paperboard in food-contact tGxtilos... [Pg.2267]

Definition PEG ether of lanolin alcohol with avg. ethoxylation value of 5 Properties H LB 7.7 nonionic Toxicology TSCA listed Uses Emulsifier, emollient, stabilizer, solubilizer, cosolvent, wetting agent, dispersant, conditioner, vise, control agent for cosmetics, pharmaceuticals, creams and lotions bromo dye solvent Trade Name Synonyms Aqualose W5 [CrodaAA/estbrook] Fancol LA-5 t[Fanning... [Pg.2321]

Uses Emollient, solubilizer, refatting agent, cosolvent, moisturizer, pigment wetting agent/dispersant, counter-irritant for cosmetics, topical pharmaceuticals, cleansers refatting agent for soaps, cleansers... [Pg.2954]

Properties Yel. liq. insol. in water m.w. 532.94 m.p. 14-16 C Toxicology TSCA listed Uses Emollient, lubricant for cosmetics and pharmaceuticals gloss aid, softener, lubricant in hair and skin care preps. cosolvent and solubilizer in perfumes lubricant for metalworking, wire drawing, in textile spin finishes sperm oil substitute solubilizer for pharmaceuticals... [Pg.2991]

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