Diazoxide Corticosteroids

Drugs that may affect sulfonylureas include androgens, anticoagulants, azole antifungals, barbiturates, beta blockers, calcium channel blockers, charcoal, chloramphenicol, cholestyramine, ciprofloxacin, clofibrate, corticosteroids, diazoxide, estrogens, ethanol, fluconazole, gemfibrozil, histamine H2 antagonists, hydantoins,... 

There is a decreased effectiveness of ritodrine when the drug is administered with a -adrenergic blocking agent such as propranolol and an increased risk of pulmonary edema when administered with the corticosteroids. Co-administration of ritodrine with the sym-pathomimetics potentiates the effect of ritodrine. Cardiovascular effects (eg, arrhythmias or hypotension) of ritodrine may increase when the drug is administered with diazoxide, general anesthetics, magnesium sulfate, or meperidine... 

VASODILATOR ANTIHYPERTENSIVES CORTICOSTEROIDS Risk of hyperglycaemia when diazoxide is co administered with corticosteroids Additive effect both drugs have a hyperglycaemic effect Monitor blood glucose closely, particularly with diabetes... 

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High dosage corticosteroids can increase IgG catabolism and can also impair synthesis (Rll). No one would deny that such treatment can reduce serum hyper-IgG-globulinemia however, in over 100 patients I have never seen this result in severe AG, and in moderate AG in only 3. Diazoxide, a drug used on a long-term basis to treat idiopathic hypoglycemia of childhood, has been shown to induce IgG deficiency (Bl), but among the 18 cases in the literature (W13) and a further 6 cases observed by me, only 9 developed moderate AG, none developed severe AG, and none seemed to become prone to infection. 

Thiazide diuretics may diminish the effects of anticoagulants, uricosuric agents used to treat gout, sulfonylureas, and insulin and increase the effects of anesthetics, diazoxide, cardiac glycosides, hthium, loop diuretics, and vitamin D. The effectiveness of thiazide diuretics may be reduced by NSAlDs and bile acid sequestrants (reduced absorption of thiazides). Amphotericin B and corticosteroids increase the risk of hypokalemia induced by thiazide diuretics. 

T Effects W/ antiliypertensives, diazoxide, nitrates, EtOH T effects OF ACEIs, Li T risk of hypokalemia W/ amphotericin B, corticosteroids, mezlocillin, piperacilhn, ticarcillin i effects W/ cholestyramine, colestipol, NSAIDs EMS Monitor ECG for hypokalemia (flattened T waves) T risk of photosensitivity Rxns use caution w/ otlier diuretics, may T risk of electrolyte imbalances and dehydration may affect glucose (hyperglycemia) OD May cause dehydration, hypotension, drowsiness, headache, and fatigue symptomatic and supportive, do not do anytliing tliat would force greater fluid loss (ie, induce V)... 

The risk of hypeigl caemia is increased if diazoxide is given with other drugs with hyperglycaemic activity (e.g. the thiazides, chlo-rpromazine, corticosteroids, combined oral contraceptives). 

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