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Coronary heart disease reactions

The basic mechanisms of lipid peroxidation are well understood and described in the literature in many excellent reviews (e.g. Girotti, 1985 Gardner, 1989 Buettner, 1993). Here, apart from essential background information, we will restrict our discussion in this short overview to recent advances in our understanding of lipid peroxidation, emphasizing those aspects relevant to coronary heart disease. Some of the biological implications of these reactions will be discussed by others in this volume. [Pg.24]

A simple observation led to the identification of homocysteine as a risk factor for coronary heart disease. Homocysteine is an intermediate in metabolism of the amino acid methionine. Indeed, the first reaction in the catabolism of methionine involves the formation of homocysteine but it can be converted back to methionine in a reaction that is catalysed by methionine synthase (see Figure 22.7). [Pg.517]

The identification of hyperhomocysteinemia as an independent risk factor in atherosclerosis and coronary heart disease (Section 10.3.4.2) has led to suggestions that intakes of vitamin Be higher than are currently considered adequate to meet requirements may be desirable. Homocysteine is an intermediate in methionine metabolism and may undergo one of two metabolic fates, as shown in Figure 9.5 remethylation to methionine (a reaction that is dependent on vitamin B12 and folic acid) or onward metabolism leading to the synthesis of cysteine (trans-sulfuration). Therefore, intakes of folate, vitamin B12, and/or vitamin Be may affect homocysteine metabolism. [Pg.261]

Because ADRs are more likely to occur in the very young and the elderly, lower drug dosages may be indicated at these two extremes of the human life span. The elderly are more likely to have diseases such as cancer, coronary heart disease, dementia, diabetes mellitus, hypertension, and osteoporosis and may also have adverse nutritional reactions. Deficiencies in liver and kidney function can result in marked delay of drug detoxification and elimination. Constant review of established diagnoses and treatments is important to minimize the number of drugs administered, and care must be taken to determine whether other nutritional supplements and herbal products are being incorporated into self-treatment. [Pg.703]

In 202 patients with unstable angina pectoris, roxithromycin prevented death and re-infarction for at least 6 months after initial treatment (11). However, these findings could not be confirmed in another study in 302 patients with coronary heart disease and a seropositive reaction to Chlamydia pneumoniae who were treated with azithromycin. While global tests of markers of... [Pg.2183]

Normal human blood plasma contains 130-260 mg cholesterol per 100 ml, of which two-thirds is esterified with fatty acids and one-third is present as sterol [165]. Estimation of cholesterol has attracted much attention as the increased level of blood cholesterol is directly related to coronary heart diseases such as hypertension, atherosclerosis, and myocardial infarction. The CP nanocomposites have provided a suitable pathway for the operation of the biosensor by immobilization of the biomolecule on CP for detection of different analytes. A smart, quick, accurate determination of cholesterol in blood is an urgent need in clinical diagnosis. The following biochemical reaction occurs as a result of interaction of cholesterol oxidase (ChOx) with cholesterol ... [Pg.712]

Immunologic Ku die zi injection is made from Herba Ixertis Sonchifoliae, which is believed to improve blood circulation and is generally used to treat coronary heart disease and angina pectoris in China. However, it has been reported to cause serious allergic reactions [13 ]. [Pg.991]

The onset of coronary heart disease is directly correlated with blood cholesterol levels, and the first step in disease prevention is to lower those levels. It turns out that only about 25% of our blood cholesterol comes from what we eat the remaining 75% (about 1000 mg each day) is made, or biosynthesized, by our bodies from dietary fats and carbohydrates. Thus, any effective plan for lowering our cholesterol level means limiting the amount that our bodies biosynthesize, which in turn means understanding and controlling the chemical reactions that make up the metabolic pathway for cholesterol biosynthesis. [Pg.1]

Lipid peroxidation occurring in food products causes some deterioration in food quality such as rancid flavor, bad taste and shortening of shelf life. The intake of oxidative foods is thought to cause serious diseases such as enlargement of liver (I) or necrosis of epithelium tissue. The factors involved in these diseases were lipidperoxidants and low-molecular conqjounds produced at the latter stage of oxidative reaction (2). Furthermore, cancer, coronary heart diseases and Alzheimer s diseases were also reported to be partially responsible for oxidation or free-radical reaction (5-6). In order to prevent foods from these deterioration and prevent us from serious diseases, it is very inq>ortant to inhibit... [Pg.289]

Rapid peripheral intravenous injection of concentrated ionic contrast media produces a brief rise in systemic arterial pressure followed by a prolonged fall the diastolic pressure decreases more than the systolic pressure and the heart slows the pulse contour changes, and the venous pressure rises the arterial hypotension is more marked if injection is rapid. The electrocardiogram can show flattening, splitting, or T-wave inversion tachycardia is probably compensatory, as are the concomitant increases in venous pressure and pulmonary arterial pressure. Hypotension associated with a vasovagal reaction probably explained four deaths from acute coronary insufficiency (two each with iodoalphionic acid and iopa-noic acid) in patients with ischemic heart disease. [Pg.1855]

The diagnostic efficacy and the safety of Sono Vue has been assessed in 218 patients with suspected coronary artery disease who underwent echocardiography (17). Each received intravenous Sono Vue 0.5, 1.0, 2.0, and 4.0 ml in random order at intervals of at least 5 minutes between injections. There were no clinically significant changes in physical examination, vital signs, or electrocardiography. There were no serious adverse effects, even in patients who had heart failure and a history of myocardial infarction. The non-serious adverse reactions were mild and transient and required no treatment. The most common adverse effects were headache (4%) and nausea (1.4%). [Pg.3545]


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