Preventable death

The symptom of syncope in a patient with ischemic heart disease and heart failure should initially prompt concern about ventricular dysrhythmias. Based on the results of recent clinical trials of sudden death prevention in heart failure [27, 28], most patients with low ejection fraction and advanced ischemic heart disease will likely be treated with an... 

As left ventricular dysfunction is a major predictor of sudden arrhythmic death, cardiac death and total mortality, it can be stated that in general sudden cardiac death prevention is achievable with the combination of an implantable cardioverter defibrillator (ICD) and medical therapy. 

On another occasion an Englishwoman, to whom he had just been introduced, mistook him for Josias Bunsen, the ambassador, and asked him if he had finished his book entitled Gott in der Gescbichte. Alas, replied Bunsen, My untimely death prevented me (II). 

The outcomes of effectiveness increasingly should be clinically relevant measures such as deaths prevented or QALYs gained, rather than mere pharmacological outcomes. 

Matsuyama Z, Yanagisawa NK, Aoki Y, Black JL 3rd, Lennon VA, Mori Y, Imoto K, Inuzuka T (2004) Polyglutamine repeats of spinocerebeUar ataxia 6 impair the cell-death-preventing effect of CaV2.1 Ca channel - loss of-fimction cellular model of SCA6. Neurobiol Dis 17 198-204... 

Assuming that the best treatment for AD is neuronal death prevention prior to the onset of the disease, novel therapeutic options and future candidate drugs for AD might be a new generation of antiamyloid vaccines, such as DNA Ap42 trimer immunization [146] or vaccines developed with new immunogenic... 

Costantini O, Hohnloser SH, Kirk MM, et al. The ABCD (Alternans Before Cardioverter Defibrillator) Trial Strategies Using T Wave Alternans to Improve Efficiency of Sudden Cardiac Death Prevention. J Am Coll Cardiol 2009 53(6) 471-9. 

Guidelines implementing this legislation were not drafted until 1990 since then the rules have been subject to extensive debate. Revised guidelines were released in August 1992 and will be followed for all major submissions to the PBAC as of January 1993. The guidelines recommend the use of final outcome measures, such as cost per year of life saved, cost per death prevented, or cost per quality-adjusted year of life, to evaluate... 

We have observed decreases in serum bilirubin levels of up to 50% and appearance of conjugated bilirubin products in the native bile up to nine weeks post transplantation, indicating metabolic activity in the transplanted cells. While promising, these results were difficult to consistently reproduce, and successful hepatocyte transplantation was limited by cell injury and hypoxia at the time of transplantation. Cell death prevented consistently adequate cell mass engraftment to replace function. 

Every effort should be made to provide a private, dignified, and peaceful death. Prevention of physical discomfort and mental anguish is a paramount consideration. 

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