Neovascularization, cornea

Bg (pyridoxine) Cornea (neovascularization) Retina (gyrate atrophy)... 

Fig. 1. Rat cornea neovascularization in response to MIG (ELR CXC chemokine), IL-8 (ELR CXC chemokine), bFGF, and VEGF, or combinations of these cytokines with MIG. Panels A, B, C, E, and G, represent the corneal neovascular response to a hydron pellet containing vehicle control, MIG (10 nAf), IL-8 (10 nM), bFGF (10 nM), or VEGF (10 nAf), respectively. Panels D, F, and H represent the corneal neovascular response to a hydron pellet containing IL-8+MIG, bFGF+MIG, VEGF+MIG, respectively. All panels are at 25X magnification.

Alternatively, the virus could use ECRF3 to exploit the cytokine functions of its chemokine ligands to ensure a cytosolic milieu that has been optimally conditioned for replication or for the establishment of latency. In this regard, IL-8 and GROa are angiogenic in certain in vivo models, including the rat cornea neovascularization model (67), and are chemotactic for endothelial cells in vitro, although the receptor responsible for this activity has not been defined. 

No exposure-related clinical signs or lesions of systemic toxicity and no oncogenic responses were observed in rats exposed by inhalation at concentrations of 0, 15, 45, or 135ppm 6 hours/day, 5 days/week, for 24 consecutive months." Dose-related changes occurred in the anterior portion of the olfactory epithelium and consisted of atrophy of the neurogenic epithelial cells followed by progressive hyperplasia of the reserve cells and ultimately loss of the upper epithelial cell layer. Opacity and neovascularization of the cornea were also observed in methyl acrylate-exposed animals. 

The big diameter LK was first introduced in the year 2000 by Vajpayee [50] for a use in the surgical treatment of sequelae due to comeal bums. Vajpayee has recorded the results of nine ocular operations. The intervention begins with a conjunctival peritectomy over 360°. The conjunctiva is reclined backwards. The recipient cornea is trepanned to a 12-13 mm diameter and to a 300 pm depth. The lamellar graft is sampled via a trepanation at 1.5 mm back to the limbus in order to include LSC. It is then sutured by 24 10/0 nylon stitches. Despite the limbus allograft, no immunosuppressive therapy has been prescribed. The operation was practiced about 30 months after the occurrence of the bum. Results are recorded after a 7.4 month observation. The visual acuity has improved in six cases. No recurrence of the comeal neovascularization and no... 

Neovascularization (NV) is the formation of new blood vessels from existing vessels. Figure 39.2 shows neovascularization that has developed in a rabbit cornea after a mustard exposure. Normally the cornea is avascular, and thus, to become vascularized, vessels in the periphery (the limbus and beyond) must respond to signals from the... 

The vessels associated with the phlyctenule also migrate toward the center of the cornea and produce focal neovascularization. Triangular corneal scars with their base at the limbus often form as phlyctenules heal. These scars can be vascularized. Scarring in the central cornea can decrease visual acuity if the phlyctenulosis is long-standing. Corneal perforation in phlyctenulosis is rare but has been reported. 

Noninfectious indolent epithelial ulcers also can occur in HSK.These ulcers, formerly referred to as metaherpetic lesions, tend to be ovoid, 2 to 8 mm in size, with smooth rolled edges. They may be caused by damage to the epithelial basement membrane due to inflammation, tear film abnormalities, neurotropic cornea, or toxicity from antiviral medications. These ulcers may be recalcitrant, resulting in neovascularization and scarring. 

Gimbrone, M. A., Cotran, R. S., Leapman, S. B. and Folkman, J. (1974a) Tumor growth and neovascularization an experimental model using the rabbit cornea. J. Natl. Cancer Inst. 52,413-427. 

The biocompatibility of poly(CPP), poly(TA), and copolymers of CPP SA and CPP TA implanted in the corneas of rabbits was studied. Six weeks after implantation, the cornea remained clear and showed no evidence of corneal edema or neovascularization, indicating biocompatibility of the polymer matrix implant. 

Recognizing the fact that ROS play a role in the pathogenesis of mustard-induced ocular injuries, compounds that inhibit the formation of ROS or prevent their toxic effects would be beneficial in the treatment of mustard-induced ocular injuries. The topical application of low concentrations of Zn/DFO or Ga/DFO after comeal exposure to nitrogen mustards markedly reduced conjunctival, comeal, iris, and anterior chamber injury. In the cornea, the healing of epithehal erosions was faster, the long-term opacification was reduced, and the levels of neovascularization were lowered. In the anterior chamber, decreased inflammation and better maintenance of intraocular pressure were achieved. Cataractous changes were also notably milder (Banin et al., 2003). 

The biocompatibility of EVAc matrices has been studied quite extensively. When implanted in the cornea of rabbits—which is sensitive to edema, white-cell infiltration, and neovascularization associated with inflammation— purified EVAc caused no inflammation, while unpurified EVAc caused mild inflammation [33]. After seven months of subcutaneous implantion, only a thin capsule of connective tissue surrounded EVAc implants no inflammation was present and the adjacent loose connective tissue was normal [34]. When implanted in the brains of rats, EVAc matrices produced only mild gliosis... 

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