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Signs and symptoms of thromboembolic or thrombotic disorders, including loss of coordination, numbness or weakness of an extremity, shortness of breath, speech or vision disturbance, sudden severe headache, and pain in the chest, leg, or groin... 

MS is a central nervous system disorder in which myelin is gradually destroyed in patches throughout the brain or spinal cord, or both. This loss of myelin interferes with nerve transmissions and leads to muscular weakness, loss of coordination, numbness, tremors, and speech and vision disturbances. MS is thought to be an autoimmune disease. 

Other symptoms—other common symptoms of FM include chest pain, morning stiffness, cognitive or memory impairment, dizziness, impaired coordination, numbness and tingling sensations, irritable bladder, twitching, dry eyes or mouth, and skin sensitivities. 

Ion Coordination numb par Ion Coordination numbar pm Ion Coordination numbar pm... 

Figure 3.16. Hydrogen chemisorption on supported metals plots of H/Mtot versus (12-N) where N is the first-Hshell coordination numb determined by EXAFS (a) Pt/Al203 (b) RI1/AI2O3 (c) Ir/Si02 and Ir/Al203 (d) curve for estimating dispersion D from (12-JV) (see text).

Numbness and tingling of the limbs, twitching of the facial muscles, inability to coordinate muscular activity, nausea, visual hallucinations, and a deep stupor are characteristic. Macroscopia is frequent, entering into Waika belief about the spirits that dwell within the plant. Levitation, or a sensation of floating in air or flying, is reported. 

Interferes w/ DNA synth Dose Adults. Anaerobic Infxns 500 mg IV q6-8h Amebic dysentery 750 mg/d PO for 5-10 d Trichomoniasis 250 mg PO tid for 7 d or 2 g PO X 1 C. difficile 500 mg PO or IV qSh for 7-10 d (PO preferred IV only if pt NPO) Vaginosis 1 applicator-full intravag bid or 500 mg PO bid for 7 d Acne rosacea/skin Apply bid Peds. 30 mg/ kg PO/IV/d q6H, 4 g/d max-s-. Amebic dysentery 35-50 mg/kg/24 h PO in 3 -s- doses for 5-10 d Rx 7-10 d for C. difficile-, in hepatic impair Caution [B, M] Avoid EtOH Contra 1st tri of PRO Disp Tabs, caps, IV, topical lotion, intravag gel, cream SE Disulfiram-like Rxn dizziness, HA, GI upset, anorexia, urine discoloration Interactions t Effects W/ cimetidine T effects OF carbamazepine, fluorouracil, Li, warfarin -1- effects W/ barbiturates, cholestyramine, colestipol, phenytoin EMS t Effects of anticoagulants concurrent EtOH use can cause disulfiram-like Rxn (tach, N/V, sweating, flushing, headache, blurred vision, confusion) may cause a metallic taste and discolored urine OD May cause N/V/D, numbness in hands and feet, Szs, and loss of coordination symptomatic and supportive... 

Pyridoxine [Vitamin B ] [Vitamin B Supplement] U e Rx prevention of vit B6 deficiency Action Vit supl Dose Adults. Deficiency 10-20 mg/d PO Drug-induced neuritis 100-200 mg/d 25-100 mg/d prophylaxis Peds. 5-25 mg/d x 3 wk Caution [A (C if doses exceed RDA), +] Contra Component aUCTgy Disp Tabs 25, 50, 100 mg inj 100 mg/mL SE Allergic Rxns, HA, N Interactions -1- Effects OF levodopa, phenobarbital, phenytoin EMS Can be used as an antidote for isoniazid poisoning OD May cause sensory nerve damage (numbness, tingling, reduced sensation) and coordination problems Sxs are usually revised aft stopping pyridoxine symptomatic and supportive... 

Cerebrum and cerebellum Motor nerve tracts Sensory nerve tract Balance problems, speech problems, coordination, tremors Muscle weakness, spasticity paralysis, vision problems, bladder, bowel problems Altered sensation, numbness, prickling, burning sensation... 

The physical effects of PCP on the user can be as varied and unpredictable as the psychological reactions. At low to moderate doses, PCP produces a slight increase in breathing rate and a more pronounced rise in blood pressure and pulse rate. Respiration becomes shallow, and flushing and profuse sweating occur. Generalized numbness of the extremities and loss of muscular coordination may also occur. 

Methaqualone affects muscle movement and proper functioning of nerve sensation. Users experience paresthesia, which is a numb tingling, or pins and needles sensation, most commonly in the fingers and face. Individuals who take heavy doses of methaqualone also have a heightened pain threshold. The coordination of brain and body becomes disconnected, and nerve signals are slowed or stopped on their way to the brain s command center. While under the influence of methaqualone, users may hurt themselves without realizing it. 

A stroke results in numbness or weakness down one side facial weakness problems with balance/coordination, dysphagia, dysphasia and dysarthria and loss of consciousness (in severe stroke). 

There are useful tests to identify toxic effects on the peripheral nerves. Studies such as nerve conduction tests (NCSs) and electromyographic tests (EMGs) are used to identify the tingling or numbness of the hands or feet or associated muscle weakness. A set of neuropsychometric tests has also been developed to find behavioral effects of solvents in humans. These include but are not limited to (1) motor speed (2) hand steadiness (3) perceptual speed (4) reaction speed, eye-hand coordination, and manual dexterity (5) verbal and visual memory and learning and (6) cortical evoked potentials (electrical activity in the brain following sensory stimulation). ... 

Disturbed vision, ringing in the ears, tinnitus, loss of equilibrium, dizziness, pain, tactile disorders, tinghng, numbness, increased coldness Weakness, convulsions, tremors, paresis, twitching, lack of coordination, gait change, reflex abnormahties... 

Center metals (M-M ) Bridged ligand Terminal ligand Coor. numb er 4 d" Coordination geometry Magnetism ReC... 

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