Controlled release systems proteins

Van de Weert M, van Steenbergen MJ, Cleland JL, Heller J, Hennink WE, Crommelin DJ. Semisolid, self-catalyzed poly (ortho ester)s as controlled-release system protein release and stability issues. J. Pharm Sci 2002 91 1065-1074. 

M. van de Weert, M.J. van Steenbergen, J.L. Cleland, J. Heller, W.E. Hennink, and D.J.A. Crommelin, Semisolid, self-catalyzed poly(ortho ester)s as controlled-release systems Protein release and protein stability issues, J. Pharm. Sci., 91 (4), 1065-1074,2002. 

Bovine growth hormone, a difficult protein for which to develop controlled release systems due to its propensity toward self-aggregation and inactivation, has successfully been incorporated into polyanhydride matrices (18). The growth hormone was colyophilized with sucrose, dry-mixed with finely powdered polyanhydride, and then compression molded into 1.4-cm-diaraeter wafers, 1 mm thick. As is shown in Fig. 15, release of bovine growth hormone was well controlled over a prolonged period of time. The assay for bovine... 

Some of the most promising systems for the controlled release of proteins and peptides involve encapsulation or entrapment in biocompatible polymeric materials. The most widely used polymers to date are poly(ethylene glycol) (PEG), (D,L)-poly(lactic glycohc acid) (PLGA), poly(lactic acid) (PLA) and chitosan. Polymers could be attached to the protein to incTease the overall molecular weight of the system and so reduce the rate of absorption across the epithehum of the alveoh, or the protein could be encapsulated in the polymeric system and slowly released into systemic circulation. 

Zhu G. Stahilization and Controlled Release of Proteins Encapsulated in Poly(Lactide-co-Glycolide) Delivery Systems. Dissertation Thesis, Ohio State University, 1999, p. 199. 

Drug Delivery. Philadelphia Taylor Francis. ISSN 1071-7544. Covers basic research, development, and application principles of drug delivery and targeting at molecular, cellular, and higher levels. Topics covered include all delivery systems and modes of entry, such as controlled release systems microcapsules, liposomes, vesicles, and macromolecular conjugates antibody targeting and protein/peptide delivery. Peer-reviewed. 

Vogelhuber, W. et al., Monolithic triglyceride matrices a controlled-release system for proteins, Pharmaceutical Development and Technology, 2003, 8, 71-79. 

Maeda M, Tani S, Sano A, Eujioka K Micro-stmcture and release characteristics of the minipellet, a collagen-based drug delivery system for controlled release of protein dmgs,... 

Pea is a renewable reservoir for functional macromolecules. Pea proteins or starches can be used for packaging applications, such as films, foams and controlled release systems. The functionality of the biopolymers is influenced by technological treatments and altered by physical, enzymatic or chemical modifications. This work is aimed at obtaining detailed knowledge about the structure-property relationships of pea-based biodegradable plastics. 

Bezemer JM, Grijpma DW, Dijkstra PJ, Van Bhtterswijk CA, Feijen J. A controlled release system for proteins based on poly(ether-ester) block-copolymers polymer network characterization. J Control Release 1999 62 393—405. 

Eliaz RE, Kost J. Characterization of polymeric PLGA-injectable implant delivery system for the controlled release of proteins. J Biomed Matter Res 2000 50 388-396. 

Fu K, Klibanov AM, Langer R. Protein stability in controlled-release systems. Nat Biotechnol 2000 18 24-25. 

Polymers are mainly classified into two categories, natural and synthetic polymers (Table 30.1). Natural (water soluble) polymers are mostly obtained from natural sources. Naturally derived polymers with special focus on polysaccharides and proteins have become attractive in the biological applications of controlled release systems. Polysaccharides are a class of biopolymers constituted by either one or two alternating monosaccharides, which differ in their monosaccharide units in the length of a chain, in the types of the linking units, and in the degree of branching. ... 

Lambert, W.J. and Peck, K.D., 1995. Development of an in situ forming biodegradable poly-lactide-co-glycolide system for the controlled release of proteins. Journal of... 

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