Controlled Intracellular Trafficking

Nakamura, T., Moriguchi, R., Kogure, K., Shastri, N., Harashima, H. Efficient MHC class I presentation by controlled intracellular trafficking of antigens in octaarginine-modified liposomes. Molecular Therapy 16, 1507—1514 (2008)... 

Protein Trafficking and Quality Control Intracellular Transport Palmitoylation Endothelins... 

Since the SUMO pathway affects multiple pathways ranging from transcription, DNA repair, and intracellular trafficking over cell signaling and cell cycle control to basic metabolism, it is not suiprising that links to diseases and viral assaults are emerging. However, the field is not yet at a stage sufficiently developed for pharmacological intervention. Below we will describe selected examples for links of the SUMO pathway to diseases and viral functions. 

Shitara Y, Kato Y, Sugiyama Y. Effect of brefeldin A and lysosomotropic reagents on intracellular trafficking of epidermal growth factor and transferrin in Madin-Darby canine kidney epithelial cells. J Control Release 1998 55(1) 35 3. 

The molecular characterization of different 5-HT receptor subtypes has simplified fhe elucidation of gene transcription, mRNA processing, and translation as well as intracellular trafficking and posttranslational modification relevant to synaptic and postreceptor signaling. Transcriptional control regions... 

The intron/exon, 5 UTR, 3 UTR, and the poly-A tail all affect gene expression by modulating the turnover and intracellular trafficking of the transcript. The promoter, usually accompanied by an enhancer element, controls the number of transcripts that are synthesized. The enhancer, acting through the promoter, can dramatically increase gene expression. 

Seib FP, Hann A, Jones AT, Duncan R. Establishing a quantitative subcellular fractionation method in B16F10 cells Use to monitor the intracellular trafficking of polymer therapeutics. Proceedings of the International Symposium on Controlled Release of Bioactive Materials 2003 30 519-520. 

Survival and proliferation within mammalian cells are key virulence features of bacterial pathogens with an intracellular life cycle (1). Such bacteria have evolved sophisticated mechanisms to avoid intracellular bactericidal functions of host cells, many of which aim to modulate host functions to control their intracellular trafficking and reach or generate a niche permissive for replication. An essential step in our understanding of the intracellular pathogenesis... 

Chiu YL, Ho YC, Chen YM, Peng SF, Ke CJ, Chen KJ, Mi FL, Sung HW. The characteristics, cellular uptake and intracellular trafficking of nanoparticles made of hydrophobicaUy-modified chitosan. J Control Release. 2010 146(l) 152-9. 

Movement is an essential function in cellular system. Chemical interactions of proteins are microscopic movements of proteins, namely, diffusion, transport and the collision among the proteins. Vesicles containing proteins move to specific sites within cell for their destined functions. Chromosomes move to separate from each other during cell division. Cytoskeleton dynamically forms bundles and networks to afford routes for the intracellular trafficking and to control the physical architecture of the cell. Cells themselves move by migration. Within multicellular structure, cell movement drives the morphogenesis and preserves the homeostasis. Measurement of these various movements provides quantitative information that is inevitable for understanding the cellular system. 

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