Controlled trafficking

Heuss SF, Tarantino N, Fantini J, et al. A glycosphingolipid binding domain controls trafficking and activity of the mammalian notch ligand delta-Kke 1. PloS One. 2013 8(9) e74392. 

Anhydride has been used for the illegal manufacture of heroin [561-27-3] (acetyknorphine) and certain other addictive dmgs. Regulations on acetic anhydtide commerce have long been a feature of European practice. After passage in 1988 of the Chemical Diversion and Trafficking Act, there is also U.S. control. Orders for as much as 1,023 kg acetic anhydtide, for either domestic sale or export, require a report to the Department of Justice, Dmg Enforcement Administration (54). 

Protein Trafficking and Quality Control Intracellular Transport Palmitoylation Endothelins... 

Protein trafficking is the transport of proteins to their correct subcellular compartments or to the extracellular space ( secretory pathway ). Endo- and exocytosis describe vesicle budding and fusion at the plasma membrane and are by most authors not included in the term protein trafficking. Protein quality control comprize all cellular mechanisms, monitoring protein folding and detecting aberrant forms. 

The pharmacological manipulation of protein folding, trafficking, and quality control is still challenging, but a lot of progress has been made recently. 

Protein Trafficking and Quality Control. Table 1 Examples of diseases associated with folding-defective, mutant proteins, and pharmacological chaperones used to correct misfolding in vitro... 

Since the SUMO pathway affects multiple pathways ranging from transcription, DNA repair, and intracellular trafficking over cell signaling and cell cycle control to basic metabolism, it is not suiprising that links to diseases and viral assaults are emerging. However, the field is not yet at a stage sufficiently developed for pharmacological intervention. Below we will describe selected examples for links of the SUMO pathway to diseases and viral functions. 

Trafficking is controlled movement of a protein from one subcellular location to another. 

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