Control of microbial contamination

Maximum Residual Disinfectant Level (MRDL) - The highest level of a disinfectant allowed in drinking water. There is convincing evidence that addition of a disinfectant is necessary for control of microbial contaminants. 

Control of microbial contamination 3.2 Aseptic areas additional requirements... 

Control of microbial contamination during manufacture general aspects... 

Monitoring pharmaceutical ingredients, water for pharmaceuhcal purposes, the manufacturing environment, and finished products submitted to the laboratory to demonstrate control of microbial contamination of the pharmaceutical products manufactured... 

Australian Pharmaceutical Manufacturers Association ( ) (1990), The Control of Microbial Contamination in Nonsterile Pharmaceutical Products for Human Use, , Canberra, Australia. 

F Production and process controls Process control systems, reprocessing control of microbial contamination... 

The major source of microbial contamination of controlled environments is personnel. Since the major threat of contamination of product being aseptically processed comes from the operating personnel, the control of microbial contamination associated with these personnel is one of the most important elements of the environmental control program. Personnel training should be conducted before the qualification and validation practice [13]. 

Oldham GB, Andrews V Control of microbial contamination in unpreserved eyedrops. BrJ Ophthalmol 1996 80 588-591. 

Sterility testing requires a strict control of microbial contamination challenge from outside the controlled environment, but not of the particulate contamination liberated by the process itself. Hence, a positive-pressure isolator in a controlled environment, using... 

Bloomfield SF. Control of microbial contamination part 2 current problems in preservation. Br ] Pharm Pract 1986 8 72, 74-76, 78, 80. 

The control of microbial contamination in solid immobilized preparations is often simpler than for soluble protein. 

Recently, 275 tons of Lebanon bologna were recalled by a Pennsylvania processor due to possible salmonella contamination (Anonymous, 1995b). This emphasizes the importance of good manufacturing practices and careful control of microbial contamination in processing of IM meat products. 

Williams, T. M., Haack, T. K., Robbins, J. R., Gropp, R. W., 1992. Biocide treatment for control of microbial contamination and fuel quality problems. In Proceedings of the 4th International Conference on Stability and Handling of Liquid Fuels. U.S. Department of Energy, pp. 861-876. 

Potassium N-methyldithiocarbamate is a broad spectrum microbicide. As it is of limited stability, it is mainly used for short-term control of microbial contamination. 

In the case when it is necessary to do some intervention it is necessary to ponder the possible side effects. One needs to assess the global impact on the object of the intervention (there could be also other impacts on the surrounding environment). This applies to all possible interventions even preventive ones. In Fig. 1.2 it is possible to observe a situation where the use of a metallic net to protect the statuary of a church has contribute to the development of brownish stains in the statues. This must be kept on mind to be alert to some proposals such as the application of brass strips on object sites exposed to run-off rainwater having in mind the control of microbial contamination that, as discussed in Warscheid, and Braams (2000) could lead to greenish stains. Of course sometimes is a question of choosing the lesser of two evils (however in the previous case one could be altical about which would be... 

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