Container sealing

Glass ampoules are heat sealed outside of the freeze-drier using either draw-sealing or tip-sealing techniques. It has been suggested that while draw-sealing will ensure an acceptable and safe seal, tip-sealing may be less 

The risk of vial breakage may be significant during oversealing particularly when automatic equipment is used for this operation. Two types of mechanical oversealers are commonly used  

Both types of oversealer require careful adjustment to ensure an acceptable seal with minimum vial breakage. Alternatively, vials may be sealed with a screw cap rather than an aluminium overseal and these alternatives may be safer to use when hazardous products are processed. 

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Small and fragile products should be held in containers and the container sealed and marked with the inspection status. Large products should either carry a label or have a related inspection record. 

Packing can be classed as a special process since once the units are placed in the containers and the containers sealed, the only way to subsequently verify the right units are in the right containers is to break the seal and inspect the contents. Your packing controls should therefore give you sufficient confidence concerning the contents of containers without having to break the seals. 

The compounds KAu and RbAuj have been prepared by melting the pure metals in an alumina container sealed in an iron bomb. ... 

It is common to use compressed gas to force the liquid N2 through the transfer tube. If transfers are frequent, pressurization and depressurization of the container leads to waste and contamination of the liquid. To avoid these drawbacks, one can leave the container sealed by a blowoff valve (release for an overpressure of about 0.2 atm). A valve in the transfer tube allows liquid N2 to be drawn under this pressure when desired. 

Development of the thin-layer chromatogram is accomplished by placing a small amount of eluent in the bottom of a suitable container, placing the spotted thin layer in the container, sealing it, and allowing the eluent to ascend the layer through capillary action. 

Annex K contains seal chamber runout illustrations. 

The chemical name for rust is iron oxide. Normally, iron rusts more quickly if it is wet. However, iron can be kept underwater without rusting if the water is first boiled, to drive off its oxygen, and the container sealed with oil to prevent the oxygen from re-entering. 

The lower instruments monitors a closed container sealed off at time zero. The blue and the yellow instruments show the same concentrations from time zero until the yellow instruments reaches the end of the catalyst bed, illustrating the equivalence between flow... 

On laminar flow bench, open the bag to expose the stoppers. Using sterile forceps, randomly select 20 stoppers, transferring them to a sterile, nonpyrogenic sample container. Seal the container after the transfer of stoppers is complete. 

The suspension obtained is dispensed into aluminum containers sealed with metering valves by means of the pressure-filling technique. 

The differences in primaiy container sealing are based on how energy is transferred or applied. 

The primary objective of miniature battery design is to maximize the energy density in a small container. A compromise must be reached, however, since volumetric energy density decreases as cell volume decreases and the dead volume due to containers, seals, etc. becomes increasingly significant. A plot of energy density as a function of total volume is given in Fig. 3.28 for the zinc-mercuric oxide and zinc-silver oxide systems. 

Figure 26.8 (A) Suction equipment for TLC. (B) Equipment for polarography of small volumes 1, upper part of ground joint 2, mantle of the ground joint 3, electrolysis cell 4, water container sealing the inner space. [From Ref. 84.]...

Sample, stored in an appropriate clean container (sealed if solvent loss is an issue) Controlled-rate or controlled-stress rotational rheometer with Computer control and appropriate software for instrument control, data acquisition, and model fitting... 

Ethylenethiourea has a wide variety of uses in addition to vulcanization, a principal application since 1948. The curing process converts most of the ETU to other compounds, but traces of it are still found in the rubbers. Neoprene (polychloroprene) is found largely in automotive parts, wire and cable insulation, construction and adhesives. Consumer products containing neoprenes include container seals (e.g., aerosol dispensers) and shoes. It is also an intermediate in the manufacture of antioxidants, dyes, fungicides, insecticides, pharmaceuticals, synthetic resins, and a constituent of plating baths. 

Add several drops of the preservation chemical, shown in Appendix 13, to the container. Seal the container and invert it several times to mix the content. 

If a mixture of ice and water at 1 atm pressure and 0°C is placed in an insulated container and all of the air is pumped away and the container sealed, what will happen As was shown in the previous section, at pressures lower than 1 atm, the melting point of ice is above 0°C. Water will, therefore, be solid at 0°C and reduced pressure. However, when some liquid water freezes, its latent heat is released and the temperature of the system is slightly increased. Equilibrium is reestablished at the higher temperature and reduced pressure. The pressure in the system is the vapor pressure of both liquid and solid water slightly above 0 K. The new equilibrium point of the system is called the triple point of water and is at 0.0098°C and 611 Pa. Three phases—solid, liquid, and gas—coexist at the triple point, and the chemical potential of water in each of the phases must be equal ... 

Figure 031. This apparatus can be replaced with any standard distillation apparatus, or standard fractional distillation apparatus Alcohol stills can also be used, but may undergo corrosion in the distillation pot due to the presence of sulfuric acid. The diethyl ether should be re-distilled using a standard fractional distillation apparatus, or equivalent. After redistillation, the ether should be stored in a proper container such as a metal can, or glass container, sealed air-tight, and filled to the top (to minimize air gaps), and these containers should be stored in a refrigerator until use. Note the heating mantle portrayed in the illustration can be replaced by a Bunsen burner, hot plate, stovetop, steam bath, or oil bath if desired.

The sublimate will appear more yellow-orange and even reddish in areas. Collect and sublime a third time. After this third sublimation, the crystals will appear very yellow-orange to red-yellow and are ready for use. Store them in a glass container sealed from moisture. Next, we need a very strong alcohol, 95% at least, and preferably from red wine. When we have prepared these two ingredients, they are combined at the New Moon in the proportion of four parts Sal Ammoniac to ten parts Alcohol. Seal them in a glass vessel and let digest at about 40°C for a month at least. 

Place the resin into a suitably sized distillation vessel and proceed to distil as in the acetate work. Drops of a blood-red oil will come over, which are carefully collected by dissolving them into alcohol. Rinse any of the oil adhering to the glassware out with alcohol and combine all of the liquid into a container. Seal and allow it to stand for several days, then decant the clear tinted extract for use. This Fixed Tincture of Antimony has powerful healing properties unrecognized by modern medicine. 

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