Genetic conservation

The use of sequence information to frame structural, functional, and evolutionary hypotheses represents a major challenge for the postgeno-mic era. Central to an understanding of the evolution of sequence families is the concept of the domain a structurally conserved, genetically mobile unit. When viewed at the three-dimensional level of protein structure, a domain is a compact arrangement of secondary structures connected by linker polypeptides. It usually folds independently and possesses a relatively hydrophobic core (Janin and Chothia, 1985). The importance of domains is that they cannot be divided into smaller units— they represent a fundamental building block that can be used to understand the evolution of proteins. 

To maintain and conserve genetic diversity through attention to on-farm management of genetic resources. 

Engels, J.M.M. Ebert, A Thormann I. and M.C. de Vicente (2006) Centres of crop diversity and/or origin, genetically modified crops and implications for plant genetic resources conservation.- Genetic Resources and Crop Evolution 53 (8), 1675-1688. 

Stuart JM, Segal E, Roller D, et al. A gene-coexpression network for global discovery of conserved genetic modules. Science. 2003,302,249-255. 

Rooney AAA, Luebke RWR, Selgrade MKM, Germolec DRD (2012) Immunotoxicology and its application in risk assessment. Conserv Genet 101 251-287... 

Necrotic cell death differs markedly from apoptosis, a morphologically distinct pathway to cell death under the control of conserved genetic elements (Table 1). Apoptotic cell death (a.k.a. programmed cell death or cell suicide) is an active cell death mechanism that functions to remove unwanted cells from a tissue in a controlled, orderly fashion. It generally affects cells in isolation, which exhibit a suite of conserved morphological and biochemical features that contrast sharply with those observed during necrosis. 

Mundy, N, 1, et al. (2004), Conserved genetic basis of a quantitative plumage trait involved in mate choice. Science, 303, 1870-3,... 

Fritsch, P. and Rieseberg, L.H. (1996) The use of random amplified polymorphic DNA (RAPD) in conservation genetics, in Molecular Genetic Approaches in Conservation (eds. T.B. Smith and R.K. Wayne), Oxford University Press, New York, pp. 54-73. 

Indeed, the brain vescicle of protochordates has been deeply and suddenly modified in a much more complex brain that has been maintained in its basic topography until mammals. This morphogenetic event might have coincided with duplication, recruitment, and stabilization of conserved genetic functions into new cell-types that in turn, have refined/modified or created new versions of pre-existing developmental pathways possibly by increased combinations of new molecular interactions (Holland, 1999 Acampora et al., 2001). Indeed, it might be that... 

Acampora, D., Avantaggiato, V., Tuorto, F., Barone, P., Reichert, H., Finkelstein, R., Simeone, A. 1998a. Murine Otxl and Drosophila otd genes share conserved genetic functions required in invertebrate and vertebrate brain development. Development 125, 1691-1702. 

Tlie elucidation of genetic contributions to senescence in Drosophila melanogaster and Caenorhabditis elegans and their relationship points towards fundamental evolutionary conserved genetic and biochemical mechanisms. 

Conserved genetic, protein, and metabolite annotations Consistent analysis approaches Provide the molecular basis of pharmacological and toxicological responses Effective and informative database Bioinfamatics... 

No phylogeographic structure in the circumpolar snowy owl (Bubo scandiacus). Conservation Genetics 10, 923-933. 

BEARLiN A R and TiKEL D (2003) Conservation genetics of Murray-Darling Basin fish silver perch Bidyanus bidyanus), Murray cod (Maccullochella peelii), and trout cod (M. macquariensis), in Phillips B (ed.). Managing fish translocation and stocking in the Murray-Darling Basin workshop, Canberra, 25-26 September 2002 statement, recommendations and supporting papers. Sydney World Wildlife Fund, 59-83. 

FAULKS L K, GILLIGAN D M and BEHEREGARAY L B (2010a) Evolution and maintenance of divergent lineages in an endangered freshwater fish, Macquaria australasica. Conservation Genetics, 11,921-934. 

FRANKHAM R and LOEBEL D A (1992) Modelling problems in conservation genetics using captive Drosophila populations rapid genetic response to captivity. Zoo Biology, 11, 333-342. 

FRANKHAM R, BALLOU J D and BRISCOE D A (2002) Introduction to conservation genetics. Cambridge Cambridge University Press. 

GiLLiGAN D M (2000) Conservation genetics and stocking for spedes recovery programs, in Moore A and Hughes R (eds). Proceedings of a workshop on stock enhancement of marine and freshwater fisheries. Lismore Australian Society for Fish Biology and Southern Cross University, 39-45. 

LYNCH M and o hely m (2001) Captive breeding and the genetic fitness of natural populations. Conservation Genetics, 2,363—378. 

F., Yeh, P., Blanche, F., and Petre, D. (1991) Purification, cloning and primary stmcture of a new enantiomer-selective amidase from a Rhodococcus strain stmctural evidence for a conserved genetic coupling with nitrile hydratase. J. Bacteriol., 173, 6694-6704. 

Lipow, S.R., K. Vance-Borland, J.B. St. Clair, J. Henderson and C. McCain. 2004. Gap analysis of conserved genetic resources for forest trees. Conservation Biology 18 412-423. 

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