Gene sharing

Fig. 16.3 Literature network of 26 genes shared in mice, which were immunized with diphtheria toxoid or tetanus toxoid and different adjuvants (5). The 26 shared genes were submitted to the PubGene software (version 2.6) together with the key word immune response. The gene names were translated into primary symbols by the software. These primary symbols formed a literature network with a functional relationship to immune response, confirming their role in immune response after vaccination. The number of cocitations ranged from 1 to 5198...

When two genes share readily detectable sequence similarities (nucleotide sequence in DNA or amino acid sequence in the proteins they encode), their sequences... 

Fibrinogen synthesis is stimulated by hormones such as the glucocorticoid dexamethasone or suppressed by the estrogen estadiol-17 (Amrani et al., 1983 Wangh et al, 1983). The three fibrinogen genes share a... 

Mosser J, Douar AM, Sarde CO, et al. Putative X-linked adrenoleukodystrophy gene shares unexpected homology with ABC transporters. Nature 361 726-730,1993. 

Relationship to person with schizophrenia Relative risk (%) Percent (%) genes shared on average I... 

Chromosome 2 unjque gXon 1 tor each UGT1A gene shared Exons... 

An alternative view of the evolution of functionally novel proteins includes gene-recruitment [12] or gene sharing [13]. In this model, a period of bifunctionality of a single gene product precedes the duplication event upon which one copy maintains the ancestral function while the other adopts the new function. The various aspects of bifunctionality can hereby range from conservation of structural properties as demonstrated for crystallins [14] to what O Brian and Herschlag [15] call promiscuous activity in ancestral structures. 

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