Cell suicide

Dhein J, Walczak H, Baumler C, Debatin KM, Krammer PH Autocrine T-cell suicide mediated by APO-l(Fas/CD95). Nature 1995 373 438-441. 

Another case is associated with the role of H202 in apoptosis the programmed cell suicide. 

Bishop CM (1999) The maximum oxygen consumption and aerobic scope of birds and mammals getting to the heart of the matter. Proc R Soc Lond B Biol Sci 266 2275-2281 Blackstone NW (2000) Redox control and the evolution of multicellularity. Bio Essays 22 947-953 Blackstone NW, Green DR (1999) The evolution of a mechanism of cell suicide. BioEssays 21 84-88... 

Fischers medium is required for the stem cell suicide assay (see Subheading 3.3.) and is made by mixing the following 437.5 mL Sterile ultra-pure... 

N. Wniiams. Research News, Thyroid disease A case of cell suicide. Science, 275, 926, 1997. 

Chi S, et al. Oncogenic Ras triggers cell suicide through the activation of a caspase-independent cell death program in human cancer cells. Oncogene 1999 18 2281-2290. 

The Smac protein promotes apoptosis by neutralizing the lAP proteins through interactions of the Smac N-terminal region with the BIR domains of the lAP (31, 32). The interaction between Smac and lAP proteins disrupts the LAP inhibition of caspases, which allows caspase activation and eventual cell suicide. In vivo and in vitro studies reveal that cell kiUing via either the intrinsic or the extrinsic pathways can be enhanced by Smac mimetics (33-36). Collectively, these results suggest that Smac mimetics that bind to the BIR domains of the lAPs extricate the caspases in a manner analogous to Smac. 

Necrotic cell death differs markedly from apoptosis, a morphologically distinct pathway to cell death under the control of conserved genetic elements (Table 1). Apoptotic cell death (a.k.a. programmed cell death or cell suicide) is an active cell death mechanism that functions to remove unwanted cells from a tissue in a controlled, orderly fashion. It generally affects cells in isolation, which exhibit a suite of conserved morphological and biochemical features that contrast sharply with those observed during necrosis. 

Print, C. G. Loveland, K. L. Germ cell suicide new insights into apoptosis during spermatogenesis. Bioessays 22 (2000) 423-30. 

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