Conformal devices

The use of a bioadhesive, polymeric dosage form for sustained dehvery raises questions about swallowing or aspirating the device. The surface area is small, and patient comfort should be addressed by designing a small (less than 2 cm ), thin (less than 0.1 mm (4 mil) thick) device that conforms to the mucosal surface. The buccal route may prove useful for peptide or protein dehvery because of the absence of protease activity in the sahva. However, the epithelium is relatively tight, based on its electrophysiological properties. An average conductance in the dog is 1 mS/cm (57) as compared to conductances of about 27 and 10 mS/cm in the small intestine and nasal mucosa, respectively (58,59) these may be classified as leaky epitheha. 

Are the devices used to demonstrate conformance of product with specified requirements controlled, calibrated, and maintained in accordance with documented procedures ... 

Should you not use measuring devices in your organization, these requirements will not apply. If your means of verification are limited to visual inspection or professional judgement, as is the case with organizations that deal only with documentation, you will have no devices to control. However, you may use tools or computer software to assist you to determine conformance and these will need to be proven capable of producing a reliable result. 

When properly designed, this type of valve arrangement conforms to the ASME code. It is a pilot operated pressure relief valve in which the major relieving device is combined with and is controlled by a self-activating auxiliary pressure relief valve. See Figures 7-5A and B. 

Pressure relieving devices in process plants for process and utility steam systems must conform to the requirements of ASME [1] Par. UG-131b. This is not necessarily satisfactory to meet the ASME Power Boiler Code for applications on power generating equipment. 

Never place a block valve on the inlet side of a pressure relief device of any kind, unless it conforms to the code practice for rupture disks or locking devices. See [1] Par. UG-135(e) and Appendix M, ASME code. 

Figure 7-19 illustrates a newer approach at simplifying the dual safety relief valve installation, ASME Sect. VIII, Div. 1, UG-135(b) [1] and API RP-520, Part II Conformance [33]. Note that the SRV valves are mounted on top of each of one dual vertical connections and are bubble tight. Also see cross section view. The flow C, valves for each size device are available from the manufacturer. 

Inlet piping is held to a minimum, with the safety device preferably mounted directly on the equipment and with the total system pressure drop loss to pres.sure relief valve inlet not exceeding 3% of the set pressure in psig, of maximum relief flowing conditions [10]. To conform to code (see ASME code. Sect. Vlll, Div. l-UG-127 [1]) avoid high inlet pressure drop and possible valve chatter ... 

Each length of pipe shall be measured for conformance to wall thickness requirements. The wall thickness at any place shall not be less than the tabulated thickness minus the permissible undertolerance specified in Table 4-146. Wall thickness measurements shall be made with a mechanical caliper or with a properly calibrated nondestructive testing device of appropriate accuracy. In... 

Ensure that the instrument has appropriate output ports to drive other devices such as storage and computational facilities. Wherever possible, these ports should conform to the IEEE interface standards. 

To adjust a pressure gauge or other measuring device in order to conform closer to a test gauge or set of standards. 

The cause of the weaker G dependence must be ascribed to some particular feature of geometry, although exactly what it is has not been found. All of the three bundles involved had their rods supported and correctly positioned by wires wrapped helically around certain of the rods, and it is possible that the wires caused an unfavorable distribution of steam and water. However, it is doubtful that the wire wraps were themselves responsible, since several of the bundles conforming to Eq. (28) were also wire wrapped. (Other devices used for rod supports are suitably spaced grids and ferrules.) The explanation most probably lies in a combination of the effects of the wire wraps with the effects of given rod diameters and rod spacings. For ease of identification, the data that conform with Eq. (28) are hereafter called normal data. 

When the directives were introduced, they were applied to both new and existing devices. Thus, all device manufacturers are required to establish conformity with essential requirements, so that they can apply the CE Mark of conformity and legally market their products in the EU. 

The CE Mark is not specific to medical devices, but is used generally to indicate to European consumers that a product conforms to applicable European performance and safety requirements. It can be found on electrical equipment, children s toys and safety equipment, among other products. 

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