Compound decks

In nonfavorable cases, HTS, meaning the screening of the full compound deck, remains the only option. In favorable cases, both ligand- and structure-based in silico hits lists can be compiled using a variety of VS methods (24-26). 

Natural products have historically been a significant component of a compound deck... 

Full compound deck screening is extremely useful if you wish to find new chemotypes, and there is little information on compounds that effect the target of interest. 

Afto ordering a copy of the compound deck in the plate format of choice, the screening process can be carried out very rapidly (a matter of weeks). The screening scientist monitors the automated system continuously for both hardware and assay performance. Of all the different stages in the lead discovery process, the actual screening is now the quickest. 

Sealing compound, deck, polyurethane (polyester base)... 

Phenohc resins (qv), once a popular matrix material for composite materials, have in recent years been superseded by polyesters and epoxies. Nevertheless, phenohc resins stiU find considerable use in appHcations where high temperature stabiHty and fire resistance are of paramount importance. Typical examples of the use of phenoHc resins in the marine industry include internal bulkheads, decks, and certain finishings. The curing process involves significant production of water, often resulting in the formation of voids within the volume of the material. Further, the fact that phenoHcs are prone to absorb water in humid or aqueous conditions somewhat limits their widespread appHcation. PhenoHc resins are also used as the adhesive in plywood, and phenohc molding compounds have wide use in household appliances and in the automotive, aerospace, and electrical industries (12). 

Coa.ting S. CR has been used to coat a variety of substrates, from cloth for rainwear to concrete decks for protection against salt water. A sol-type latex is preferred to ensure good adhesion to concrete decks. A crystalline polymer latex is preferred where added durabUity is needed. The compound includes a nonionic surfactant to improve its chemical stabUity. A number of thin coatings are appUed to the surface to allow better coverage and facUitate drying. A similar formulation could be used to coat the interior of tanks, but an accelerator is needed to improve toughness. 

The gas distribution system can be composed of a network of perforated pipe, slotted or vented concrete block, or metal grating. When there are no space hmitations, single-level filters are used. In regions where footprint space is hmited, hke Japan, multiple-deck filter beds have become commonplace. If inorganic compounds are being treated, corrosion-resistant materials of construc tion are used due to the acidic by-products of the bioreaction. 

A similar mixed complex with Mn and Co is obtained by reacting the triple-decked cobalt compound XVII with hlnjCCO), ... 

Reaction of the Zn complex itself with CoClj yields different compounds by ligand transfer , e.g., T7 -CpCo(Et2C2B2Me2S) (83%), (ij -Cp)2Fe (70%) and traces of the triple-decked complex Tj -CpFe- A-(Et2C2B2Me2S)FeCp-i7. ... 

Compounds of plastic resins or rubbers used for flooring and ships decking. 

Note some Sn—C bond lengths in highly hindered compounds of 218-225 pm quoted in H. Griitzmacher, W. Deck, H. Pritzkow and M. Sander, Angew. Chem., lnt. Ed. Engl, 33, 456 (1994). 

Latex-modified mortars and concretes have become promising materials for preventing chloride-induced corrosion and for repairing damaged reinforced concrete structures. In Japan and the USA, latex-modified mortar is widely used as a construction material in bridge deck overlays and patching compounds, and for finishing and repairs [99]. Polymer-cement hydrate-... 

Fixed-Roof Tanks. The effect of internal pressure on plate structures, including tanks and pressure vessels, is important to tank design. If a flat plate is subjected to pressure on one side, it must be made quite thick to resist bending or deformation. A shallow cone-roof deck on a tank approximates a flat surface and is typically built of 3/ 16-in. (4.76-mm) thick steel (Fig. 4a). This is unable to withstand more than a few inches of water column pressure. The larger the tank, the more severe the effect of pressure on the structure. As pressure increases, the practicality of fabrication practice and costs force the tank builder to use shapes more suitable for internal pressure. The cylinder is an economic and easily fabricated shape for pressure containment. Indeed, almost all large tanks are cylindrical. The problem, however, is that the ends must be closed. The relatively flat roofs and bottoms or closures of tanks do not lend themselves to much internal pressure. As internal pressure increases, tank builders use roof domes or spheres. The spherical tank is the most economic shape for internal pressure storage in terms of required thickness, but it is generally more difficult to fabricate than a dome- or umbrella-roof tank because of its compound curvature. 

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