Compound decks screening

Full compound deck screening is extremely useful if you wish to find new chemotypes, and there is little information on compounds that effect the target of interest. 

In nonfavorable cases, HTS, meaning the screening of the full compound deck, remains the only option. In favorable cases, both ligand- and structure-based in silico hits lists can be compiled using a variety of VS methods (24-26). 

Afto ordering a copy of the compound deck in the plate format of choice, the screening process can be carried out very rapidly (a matter of weeks). The screening scientist monitors the automated system continuously for both hardware and assay performance. Of all the different stages in the lead discovery process, the actual screening is now the quickest. 

Compound stores also contain screening decks that are available mainly for the HTS laboratories. These screening decks can represent the full collection of compounds in the store or tactically organized subsets (76, 77). The choice of whether to screen a full com-... 

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