Combined chemotherapy photodynamic therapy

Canti G, Nicolin A, Cubeddu R, Taroni P, Bandieramonte G, Valentini G. Antitumor efficacy of the combination of photodynamic therapy and chemotherapy in murine tumors. Cancer Lett 1998 125(l-2) 39-44. 

Table 7. Combined chemotherapy and photodynamic therapy of A/J mice bearing Neuro 2A neuroblastoma tumors using HPMA copolymer conjugates (from [42])...

Currently, there are six major methods available for cancer treatment surgery, radiotherapy, chemotherapy, immunotherapy, hyperthermia, and photodynamic therapy. The first three are the most widely used, and the last three are under development. Surgery, radiotherapy, hyperthermia, and photodynamic therapy are primarily local, while chemotherapy and immunotherapy are primarily systemic methods. In most cases a combination of methods is used for cancer treatment. Except for surgery, the application of the remaining five methods can be improved considerably by developing quantitative understanding of mass and/or heat transfer in tumors and normal tissues. In what follows, we will discuss the problems and promises of each of these five techniques from the point of view of mass and heat transfer, and mention anti-angiogenic approaches. 

M.Y. Nahabedian, R.A. Cohen, M.F. Contino, T.M. Terem, W.H. Wright, M.W. Berns, A.G. Wile (1988). Combination cytotoxic chemotherapy with cisplatin or doxorubicin and photodynamic therapy in murine tumors. J. Natl. Cancer Imt., 80, 739-743. 

Peterson CM, Lu JM, Sun Y, Peterson CA, Shiah JG, Straight RC, Kopecek J. Combination chemotherapy and photodynamic therapy with N-(2-hydroxypropyl)methacrylamide copolymer bound anticancer drugs inhibit human ovarian carcinoma heterotransplanted in nude mice. Cancer Res 1996 56 3980-3985. 

A. Khdair, D. Chen, Y. Patil, L. Ma, Q.P. Dou, M.P.V. Shekhar, et al.. Nanoparticle-mediated combination chemotherapy and photodynamic therapy overcomes tumor drug resistance, J. Control. Release 141 (2010) 137-144. 

While most nanocapsule (NC) shells used in drug delivery systems are prepared from linear polyelectrolytes that lack any function other than that of drug container, this system employs DP not only as a polyelectrol)rte for the formation of NC shells but also as photosensitizing units for photodynamic therapy. Cell viability studies showed that combined treatment resulted in higher toxicity than either chemotherapy or PDT alone. 

Shiah, J.G., Sun, Y., Kopeckova, R, Peterson, C.M., Straight, R.C., and Kopecek, J., Combination chemotherapy and photodynamic therapy of targetable N-(2-hydroxypropyl) methacrylamide copolymer-doxorubicin/mesochlorin e(6)-OV-TL 16 antibody, /. Controlled Release, 74, 249, 2001. 

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