Combinatorial chemistry discovery research

There are examples in the literature for the application of LC/MS/NMR in namral products/ drug metabolism, combinatorial chemistry,pharmaceutical research,drug discovery,degradation products, and food analysis. LC/NMR/MS (or LC/MS/NMR as described in this entry) has also been integrated with SPE... 

One of the driving forces to apply combinatorial chemistry in drug discovery is to accelerate lead discovery and preclinical research in order to find the next drug. It is important that these combinatorial library compounds are as pure as possible when performing lead discovery screening. At this stage,... 

Hermkens, P.H.H. and Muller, G., The impact of combinatorial chemistry on drug discovery, in Ernst Schering Research Foundation Workshop Small Molecule-Protein Interactions, Vol. 42, 2003, pp. 201-220. 

Research and development When we look within drug discovery, we typically find laboratories performing combinatorial chemistry, targeted... 

Combinatorial Chemistry Technology Department, High-Throughput Discovery, Pfizer, Global Research and Development, La Jolla, CA. 

Other scientists besides biomedical researchers have employed combinatorial chemistry. In 1995, X.-D. Xiang and Peter G. Schultz, then at the University of California, Berkeley, and their colleagues published a paper in Science describing a pioneering application of this technique in materials research. As described in A Combinatorial Approach to Materials Discovery, Schultz and his colleagues performed parallel synthesis—a lot of reactions at the same time—to make an ar-... 

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