Discovery combinatorial chemistry

To speed the process of drug discovery, combinatorial chemistry> has been developed to prepare what are called combinatorial libraries, in which anywhere from a few dozen to several hundred thousand substances are prepared simultaneously. Among the early successes of combinatorial chemistry is the development of a benzodiazepine library, a class of aromatic compounds much used as antianxiety agents. 

The identification of compounds with a desired property is a central pursuit in science. In the field of drug discovery combinatorial chemistry has played an increasingly important role for identification and optimization of drug leads which target therapeutically important biomolecules. For the successful implementation of combinatorial methods, new and innovative synthesis methods have been developed. Additionally, novel conceptual approaches to the design of compounds have been pursued to more efficiently generate libraries of small molecules. 

Burke, T.J., Loniello, K.R., Beebe, J.A. and Ervin, K.M. (2003) Development and application of fluorescence polarization assays in drug discovery. Combinatorial Chemistry High Throughput Screening, 6, 183-194. 

Beeley, N., Berger, A. (2000) A revolution in drug discovery. Combinatorial chemistry still needs logic to drive science forward. BMJ[Br Med//321(7261), 581-582. 

Keywords. High throughput techniques, Chromatography, Mass spectrometry, Drug discovery Combinatorial chemistry... 

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Today, it is obvious that in drug discovery combinatorial chemistry cannot displace natural product research. However, natural product chemistry can take advantage of combinatorial strategies. In our opinion, the discovery and development of innovative therapeutic agents will substantially benefit from the... 

Shi, Y. (2006) Orphan nuclear receptors, excellent targets of drug discovery. Combinatorial Chemistry and High Throughput Screening, 9, 683-689. 

DeSimone, R.W., Currie, K.S., Mitchell, S.A., Darrow, J.W, and Pippin, D.A. (2004) Privileged structures applications in drug discovery Combinatorial Chemistry and High Throughput Screening, 7, 473-494. 

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