High-Throughput Discovery

A series of monographs in molecular diversity and combinatorial chemistry, high-throughput discovery, and associated technologies. 

Combinatorial and High-Throughput Discovery and Optimization of Catalysts and Materials... 

Combinatorial Chemistry Technology Department, High-Throughput Discovery, Pfizer, Global Research and Development, La Jolla, CA. 

Grignard additions to non-activated C=C bonds, 9, 55 high-throughput discovery, 1, 344 hydrogenation on electrophilic dihydrogen, 1, 679 and intramolecular carbene C-H insertions, 10, 182 in ionic liquids... 

Ravot, G., Wahler, D., Favre-Bulle, 0., Cilia, V. and Lefevre, F. (2003) High throughput discovery of alcohol... 

Combinatorial and High-Throughput Discovery and Optimization of Catalysts and Materials, Potyrailo, R. A. Maier, W. F., Eds. CRC Boca Raton, FL, 2006... 

As successful as these studies were in showing the general possibility of high-throughput synthesis of microporous materials in minute amounts, one should not underestimate the problems associated with such an approach. Especially if the volume of the wells decreases to the range of 10 pi or below, there are additional effects which need to be considered. These problems are probably one reason why most high-throughput discovery studies were rather directed at the formation of metal phosphates or phosphonates instead of at classical zeolites. 

Fig. 11.2 High-throughput discovery of CO2-soluble poiymers the graph shows cumulative weight % extracted in CO2 for a library of 100 polymers at five different extraction pressures (1.0-30.0 MPa). Red bar = low...

The idea to prepare solid catalysts as thin-film spots on the surface of wafer substrates had been inspired by technologies that were developed for high-throughput discovery of materials by Hanak [39], by Symyx [40-44] and others [45, 46], Hundreds to thousands of small spots of differently composed... 

Baumes, L.A., Farrusseng, D., Lengliz, M. and Mirodatos, C. (2004). Using artificial neural networks to boost high-throughput discovery in heterogeneous catalysis, QSAR Comb. ScL, 23, 767-778. 

NHases are widely found in bacteria, which thereby make use of nitriles as sole source of nitrogen by coupling with an amidase (hydrolases acting on amides that yield the corresponding carboxylic acid). This feature provides a means for new biocatalyst discovery via nitrile-selective saeening [6,7]. An iron-based colorimetric assay for NHase/amidase-activity was recently developed and optimized for high throughput discovery [8]. 

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