Combinatorial chemistry technology

Combinatorial Chemistry Technology Department, High-Throughput Discovery, Pfizer, Global Research and Development, La Jolla, CA. 

Combinatorial chemistry technology and the merging of automated library synthesis with the traditional medicinal chemistry principles to provide a more rational approach to library generation are providing pharmaceutical companies with millions of... 

However, the high capacity of HTS uncovered a second limiting process. Medicinal chemists were not able to generate compounds at a pace that could utilize the capacity of HTS. The development of combinatorial chemistry technology and its introduction into the modem medicinal chemistry laboratory gave the practicing medicinal chemist the opportunity to meet this challenge. 

Products/technologies Formerly Arris Pharmaceutical Corp., the company announced in January 1998 its plans to commercialize its capabilities in combinatorial chemistry and pharmacogenomics as well as its patented technology. The company licenses its combinatorial chemistry technology to pharmaceutical and biotech companies, and collaborates with companies wishing to screen its libraries. 

Profile Founded in 1995 with the merger of NeXagen and Vestar, the company utilizes proprietary compounds to develop therapeutics and diagnostics to serve unmet medical needs. From NeXagen, NeXstar acquired the SELEX (Systematic Evolution of Ligands by Exponential Enrichment) combinatorial chemistry technology. 

Profile Founded in late 1996, SIDDCO is a privately held company that is based on a mission to integrate and apply state-of-the-art approaches to drug discovery. SIDDCO is a combinatorial chemistry consortium that pools the resources of the consortium partners to fund a critical mass of chemists to develop the combinatorial chemistry technology database and methodologies. SIDDCO provides a dedicated team of medicinal chemists to each partner to exploit the shared technology and satisfy the drug discovery and drug optimization needs of specific projects. 

---