Colony-stimulating factors, recombinant

Granulocyte/macrophage colony-stimulating factor, recombinant... 

Armitage JO (1998) Emerging applications of recombinant human granulocyte colony-stimulating factor. Blood 92 4491-4508... 

The yeast Hansenula polymorpha serves as the production system for a recombinant hepatitis B vaccine (Berna Biotech AG [8] and yeast is also used to produce granulocyte-macrophage colony stimulating factor (GM-CSF), marketed as Leukine by Schering AG. 

It overcomes the problem of source availability. Many proteins of therapeutic potential are produced naturally in the body in minute quantities. Examples include interferons (Chapter 8), interleukins (Chapter 9) and colony-stimulating factors (CSFs Chapter 10). This rendered impractical their direct extraction from native source material in quantities sufficient to meet likely clinical demand. Recombinant production (Chapters 3 and 5) allows the manufacture of any protein in whatever quantity it is required. 

Nemunaitis, J. et al., Use of recombinant human granulocyte-macrophage colony-stimulating factor in graft failure after bone marrow transplantation, Blood, 76, 245, 1990. 

Wing, E J. et al., Recombinant human granulocyte/macrophage colony-stimulating factor enhances monocyte cytotoxicity and secretion of tumor necrosis factor alpha and interferon in cancer patients, Blood, 73, 643, 1989. 

Grant, S. M., Heel, R. C. (1992). Recombinant granulocyte-macrophage colony-stimulating factor (rGM-CSF) A review of its pharmacological properties and prospective role in the management of myelosuppression. Drugs 43, 516-60. 

Lopez, A. F., Williamson, D. J., Gamble, J. R., Begley, C. G., Harlen, J. M., Klebanoff, S. J., Waltersdorph, A., Wong, G., Clark, S. C., Vadas, M. A. (1986). Recombinant human granulocyte-macrophage colony-stimulating factor stimulates in vitro mature human neutrophil and eosinophil function, surface receptor expression, and survival. 

M. A. S., Mertlesmann, R., Welte, K. (1986). Recombinant human granulocyte colony-stimulating factor Effects on normal and leukaemic myeloid cells. Science 232,61-5. 

Vadas, M. A. (1988). Recombinant human granulocyte-macrophage colony-stimulating factor (rH GM-CSF) regulates fMet-Leu-Phe receptors on human neutrophils. Immunol. 64,519-25. 

Yuo, A., Kitagawa, S., Okabe, T., Urabe, A., Komatsu, Y., Itoh, S., Takaku, F. (1987). Recombinant human granulocyte colony-stimulating factor repairs the abnormalities of neutrophils in patients with myelodysplastic syndromes and chronic myelogenous leukemia. Blood 70,404-11. 

Walter M.R., Cook W.J., and Ealick S.E. (1992), Three-dimensional structure of recombinant human granulocyte-macrophage colony-stimulating factor, J. Mol. Biol. 224, 1075-1085. 

Schrier, J.A., R.A. Kenley, R. Williams, R.J. Corcoran, Y. Kim, R.P. Northey, Jr., D. D Augusta, and M. Huberty. 1993. Degradation pathways for recombinant human macrophage colony-stimulating factor in aqueous solution. Pharm Res 10 933-944. 

Collins, D. and Y. Cha. 1994. Interaction of recombinant granulocyte colony stimulating factor with lipid membranes enhanced stability of a water-soluble protein after membrane insertion. Biochemistry 33 4521 1526. 

Trillet Lenoir V, Green J, Manegold C et al. Recombinant granuloc34e colony stimulating factor reduces the infectious complications of C34otoxic chemotherapy. Eur J Cancer. 1993 29A 319 324. 

Schwab G, Hecht T. Recombinant methionyl granuloc34e colony-stimulating factor (filgrastim) a new dimension in immnnotherapy. Ann Hematol. 1994 69 1-9. 

Drize N, Gan 0, Zander A. Effect of recombinant human granuloc34e colony-stimulating factor treatment of mice on spleen colony forming unit number and self-renewal capacity. ExpHematoL 1993 21 1289-1293. 

J. Pandit, A. Bohm, J. Jancarik, R. Halenheck, K. Koths, and S. H. Kim, Three-dimensional structure of dimeric human recombinant macrophage colony-stimulating factor. Science 258, 1358-1362 (1992). 

D. A. Hume, P. Pavli, R. E. Donahue, and I. J. Fidler, The effect of human recombinant macrophage colony-stimulating factor (CSF-1) on the murine mononuclear phagocyte system in vivo, J.Immunol. 141, 3405-3409 (1988). 

Numerous other peptides and proteins have been, or are still in development as inhalation products with the objective of systemic absorption. Examples of these are calcitonin, LH-RH antagonists, recombinant human granulocyte colony-stimulating factor and growth hormone. 

Loehrer PJ, Elson P, Dreicer R, et al. Escalated dosages of methotrexate, vinblastine, doxorubicin, and cisplatin plus recombinant human granulocyte colony-stimulating factor in advanced urothelial carcinoma an Eastern Cooperative Oncology Group trial. J Clin Oncol 1994 12 483-488. 

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