Collagen secretion

Quan TE, Cowper S, Wu SP, Bockenstedt LK, Bucala R. Circulating fibrocytes collagen-secreting cells of the peripheral blood. Int J Biochem Cell Biol 2004 36(4) 598-606. 

Plakin proteins link intracellular keratin intermediate filaments to hemidesmosomes of basal epidermal cells, or to desmosomes on suprabasal epidermal cells (Sect. 5.2.1), whereas type XVII collagen (the only collagen secreted by epithelial cells ) and integrins attach hemidesmosomes to a basal lamina. Three p 1 integrins (with al, a3 or a5 partners)... 

Type I collagen secretion Osteoid (uncalcified bone) matrix Osteoblast process Calcified bone matrix... 

Cell proliferation was not affected by benzo[a]pyrene, but a decrease in collagen secretion and an increase in cellular toxicity were noted in both the animal and human cell cultures (Stavenow and Pessah-Rasmussen 1988). 

Stavenow L, Pessah-Rasmussen H. 1988. Effects of polycyclic aromatic hydrocarbons on proliferation, collagen secretion and viability of arterial smooth muscle cells in culture. Artery 15 94-108. 

Chen XG, Wang Z, Liu WS, Park HJ. The effect of carboxymethyl-chitosan on proliferation and collagen secretion of normal and keloid skin fibroblasts. Biomaterials 2002 23 4609-4614. 

Sauvant, C., Holzinger, H., Mildenberger, S. Gelke, M. (2005a) Exposure to nephrotoxic ochratoxin A enhances collagen secretion in renal proximal tubules. Mol. Nutr. Food Res. 49, 31-37. 

B. Li, J. Chen, H. Wang, RGD peptide-congugated poly(dimethylsiloxane) promotes adhesion, proliferation, and collagen secretion of human fibroblasts, J. Biomed. Mater. Res. 79A... 

Salpeter, M. M., Liu, E., Minor, R. R., Podleski, T. R., and Wooton, J. A., 1991, Acetylcholine receptor regulation in L5 muscle cells is independent of increase in collagen secretion induced by ascorbic acid, Am. J. Clin. Nutr. 54 1184S-1187S. 

Sullivan, T. A., Uschmann, B., Hough, R., and Leboy, P. S., 1994, Ascorbate modulation of chondrocyte gene expression is independent of its role in collagen secretion, J. Biol Chem. 269 22500-22506. 

MMP-1 Interstitial collagenase Secreted One of three collagenases that can degrade the interstitial collagens, types I, II, and III... 

Reported studies have shown its anti-inflammatory effects and anti-oxidant action. It acts by thinning the stratum corneum, promoting epidermolysis, dispersing basal layer melanin and epidermal and dermal hyaluronic acid and collagen gene expression that increases through an elevated secretion of IL-6 [3]. 

The same ceUs that secrete collagen also secrete fi-bronectin, a large glycoprotein present on cell surfaces, in the extracellular matrix, and in blood (see below). Fi-bronectin binds to aggregating precollagen fibers and alters the kinetics of fiber formation in the pericellular matrix. Associated with fibronectin and procollagen in... 

After secretion from the cell, certain lysyl residues of tropoelastin are oxidatively deaminated to aldehydes by lysyl oxidase, the same enzyme involved in this process in collagen. However, the major cross-links formed in elastin are the desmosines, which result from the condensation of three of these lysine-derived aldehydes with an unmodified lysine to form a tetrafunctional cross-hnk unique to elastin. Once cross-linked in its mature, extracellular form, elastin is highly insoluble and extremely stable and has a very low turnover rate. Elastin exhibits a variety of random coil conformations that permit the protein to stretch and subsequently recoil during the performance of its physiologic functions. 

Platelets adherent to collagen change shape and spread out on the subendothelium. They release the contents of their storage granules (the dense granules and the alpha granules) secretion is also stimulated by thrombin. 

Sauk JJ, Smith T, Silbergeld EK, et al. 1992. Lead inhibits secretion of osteonectin/sparc without significantly altering collagen or hsp47 production in osteoblast-like ros 17/2.8 cells. Toxicol Appl Pharmacol 116(2) 240-247. 

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