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SPARC/osteonectin

Bone SPARC protein (osteonectin) Not bone-specific. [Pg.548]

Sauk JJ, Smith T, Silbergeld EK, et al. 1992. Lead inhibits secretion of osteonectin/sparc without significantly altering collagen or hsp47 production in osteoblast-like ros 17/2.8 cells. Toxicol Appl Pharmacol 116(2) 240-247. [Pg.572]

BM-40/osteonectin/SPARC Single chain (M, 35K) Calcium binding... [Pg.7]

Complete sequence analysis based on cDNA was achieved for osteonectin and SPARC and indicated a disulfide-bonded, four-domain structure for the protein (Fig. 12). Remarkable features of the structure are a cluster of 16 glutamic acid residues at the N terminus and an EF-hand domain located between the last two cysteine residues, both regions having the potential for calcium-binding (Bolander et al., 1988 Engel et al., 1987). Studies with BM-40 demonstrated a reversible change in a helix from 30 to 20% upon removal of calcium. The data indicate the... [Pg.32]

Kelm Jr RJ, Hair GA, Marm KG, et al. Characterization of human osteoblast and m akaryocyte-derived osteonectin (SPARC). Blood. 1992 80 3112-3119. [Pg.129]

Kamihagi K, Katayama M, Ouchi R, et al. Osteonectin/SPARC regulates cellular secretion rates of fibronectin and laminin extracellular matrix proteins. Biochem Biophys Res Commun. 1994 200 423-428. [Pg.129]

Sodek, J. et al.. Novel functions of the matricellular proteins osteopontin and osteonectin/SPARC, Connect. Tissue Res. 43,308-19, 2002. [Pg.514]

A second category of NCPs with Ca-binding properties is classified as mineraUzed tissue specific, since they are found in all the calcified connective tissues, namely, dentin, bone, and cementum. These proteins include osteocalcin (OC) and bone sialoprotein (BSP). A serine-rich phosphoprotein called dentin matrix protein 1 (Dmp-1), whose expression was first described as being restricted to odontoblasts [5], was later shown to be expressed by osteoblasts and cementoblasts [6]. Other NCPs include osteopontin and osteonectin [secreted protein acidic and rich in cysteine (SPARC)]. The fourth category of dentin NCPs is not expressed in odontoblasts but is primarily synthesized in the liver and released... [Pg.652]


See other pages where SPARC/osteonectin is mentioned: [Pg.542]    [Pg.544]    [Pg.544]    [Pg.545]    [Pg.545]    [Pg.687]    [Pg.116]    [Pg.116]    [Pg.633]    [Pg.542]    [Pg.544]    [Pg.544]    [Pg.545]    [Pg.545]    [Pg.687]    [Pg.116]    [Pg.116]    [Pg.633]    [Pg.265]    [Pg.236]    [Pg.7]    [Pg.32]    [Pg.576]    [Pg.3]    [Pg.476]    [Pg.119]    [Pg.496]    [Pg.501]    [Pg.505]    [Pg.505]    [Pg.3]    [Pg.61]   
See also in sourсe #XX -- [ Pg.544 , Pg.545 ]




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Osteonectin

SPARC

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