Pericellular matrices

The same ceUs that secrete collagen also secrete fi-bronectin, a large glycoprotein present on cell surfaces, in the extracellular matrix, and in blood (see below). Fi-bronectin binds to aggregating precollagen fibers and alters the kinetics of fiber formation in the pericellular matrix. Associated with fibronectin and procollagen in... 

V Tendon, skin and cardiovascular tissue Pericellular matrix around cells... 

You, L., Cowin, S.C., Schaffler, M. and Weinbaum, S. (2001) A model for strain amplification in the actin cytoskeleton of osteocytes due to fluid drag on pericellular matrix, em Journal of Biomechanics 34 1375-1386... 

Chondrocytes surrounded by a layer of pericellular matrix (PCM) are called chondrons. Understanding the mechanical properties of the PCM is also important in investigating the biological responses of chondrocytes to mechanical stimulation since PCM determines the mechanical environment of the chondrocytes, and may serve as a transducer to... 

The chondrocytes of the intermediate zone are more spherical than, and differ from, the cells of the superficial layer, which show surface polaritity. Chondrons are found in the intermediate layer. They consist of chondrocytes, pericellular matrix, and pericellular capsule. In this zone, the chondrocytes do not form vertical columns as extensively as is observed in the deep zone. At high magnification the collagen fibrils have a beaded appearance, which may reflect the high level of PGs seen in this region. 

Hemangiopericytoma Hypercellularity thick pericellular matrix mitoses Vimentin (-I-) Falx, tentorium meninges (extracranial) ... 

Taipale J, Koli K, Keski-Oja J. Release of transforming growth factor-beta 1 from the pericellular matrix of cultured fibroblasts and fibrosarcoma cells by plasmin and thrombin. J Biol Chem 1992 267 25378-25384. 

Montesano, R., Mossaz, A., Ryser, JE., Orel, L., and VassaUi, P. (1984) Leukocyte Interleukins Induce Cultured Endothelial Cells to Produce a Highly Organized, Glycosaminoglycan-Rich Pericellular Matrix, J. Cell. Biol. 99,1706-1715. 

S.P. Evanko, J.C. Angello, T.N. Wight, Formation of hyaluronan-and versican-rich pericellular matrix is required for proliferation and migration of vascular smooth muscle cells, Arterioscler. Thromb. Vase. Biol. 19 (4) (1999) 1004-1013. 

Maori, L., Silverstein, D., Clark, R.A.R, 2007. Growth factor binding to the pericellular matrix and its importance in tissue engineering. Adv. Drug Del. Rev. 59, 1366-1381. 

Extracellular matrix (intercellular, pericellular matrix) is composed of a variety of polysaccharides and proteins that are spontaneously organized into ordered structures. It represents a supramolecular complex, formed by a network of molecules connected to each other [31,41]. In the human body, the extracellular matrix produces highly speciaUzed structures such as cartilage of the tendon, the basal membrane and after the secondary deposition of calcium phosphate, bones and teeth. Since these structures differ both in molecular composition and methods for organizing the main components, they comprise the various forms of the extracellular matrix [31,41]. Here we draw a generalized picture of the extracellular matrix and the functional role of hyaluronan in it. 

Jiang, H., R.S. Peterson, W. Wang, E. Bartnik, C.B. Knudson, and W. Knudson. 2002. A requirement for the CD44 cytoplasmic domain for hyaluronan binding, pericellular matrix assembly, and receptor-mediated endocytosis in COS-7 cells. Journal of Biological Chemistry 277(12) 10531-10538. 

The microscale model consists of biphasic chondrons embedded in the extracellular matrix (ECM). Chondrons are chondocytes surrounded by a pericellular matrix and a pericellular capsule [24]. We assumed that cell, PCM, PC and ECM are perfectly bonded [19]. 

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