Collagen-chitosan blends

X. Wang, L. Sang, D. Luo, and X. Li, From collagen-chitosan blends to three-dimensional scaffolds The influences of chitosan on collagen nanofibrillar structure and mechanical property. Colloid. Surf. B Biointerfaces, 82 (1), 233-240, 2011. 

A. Faikrua, R. Jeenapongsab, M. Sila-asna, and J. Viyoch, Properties of -glycerol phos-phate/collagen/chitosan blend scaffolds for application in skin tissue engineering, ScienceAsia, 35,247-254,2009. 

Salome Machado, A. A., Martins, V. C. A., and Pl-epis, A. M. G. (2002). Thermal and rheological behavior of collagen chitosan blends. Journal of Thermal Analysis and Calorimetry 67, 491-498. 

X. (2011) From collagen-chitosan blends to three-dimensional scaffolds ... 

Poly(ethylene glycol) (PEG), also known as poly(ethylene oxide) (PEO), is a hydrophilic, biocompatible polyether. PEG usually refers to a material with relatively low molecular weight (e.g., several thousands), while PEO to a material with high molecular weight (e.g., over tens or hundreds of thousands). PEO is wafer soluble and therefore can be electrospun into nanofibres from its water solution (Deitzel et al., 2001). However, water solubility makes the material unstable in a biological environment. Consequently, PEO or PEG is usually used in combination with other natural (e.g., collagen, chitosan) or synthetic polymers (e.g., PLA) in blends or copolymers (Subramanian et al., 2005 Szentivanyi et al., 2009). 

P. Jithendra, A.M. Rajam, T. Kalaivani, A.B. Mandal, C. Rose, Preparation and characterization of aloe vera blended collagen-chitosan composite scaffold for tissue engineering applications, ACS Applied Materials Interfaces 5 (15) (2013) 7291-7298. 

Sionkowska A, Wisniewski M, Skopinska J, Kennedy CJ, Wess TJ. Molecular interactions in collagen and chitosan blends. Biomaterials. 2004 25 795-801. 

Wang X, Sang L, Luo D, Li X. From coUagen-chitosan blends to three-dimensional scaffolds the influences of chitosan on collagen nanofibriUar structure and mechanical property. Colloids Surf B Biointerfaces. 2011 82 233-40. 

Significant improvement of functional properties has been reported for fibers obtained from blends of chitin with various natural polymers such as cellulose, silk fibroin and glycosaminoglycans [48, 50, 51]. Fibers of chitosan blended with alginate, collagen and gelatin have been evaluated for wound dressing and artificial skin applications [52, 53, 108, 136]. 

CoUagen type I. Crosslinked collagen type 1 and 111 Silk/chitosan blends. Up to 30% chitosan Chitin... 

The use of other proteins, such as gelatin, collagen, etc., to prepare chitosan blended membranes was tried in a 7 3 ratio (chitosan protein) and the results were compared to the standard cellulose membranes. The permeability, as a function of time, of various molecules, such as urea, creatinine, uric acid, glucose and albumin, through such membranes is shown in Figures 13, 14, 15, 16 and 17, respectively. It appears that the protein blended membranes exhibited improved permeability properties with respect to small molecules compared to the standard cellulose membrane or bare chitosan. These protein blended membranes... 

Poly-L-lysine-blended chitosan, collagen-blended chitosan and albumin-blended chitosan were also considered, with collagen control material. Culture of PC12 cells and fetal mouse cerebral cortex cells on these biomaterials was used to evaluate their nerve cell affinity. The composite materials, had significantly improved nerve cell affinity compared to chitosan. Poly-L-lysine-blended chitosan exhibited the best nerve cell affinity and was a better material in promoting neurite outgrowth than collagen [328]. 

---