Collagen Blends

The process of blending collagen tvith synthetic polymers suffers from the problem of the solubility of the polymeric components in a common solvent. Collagen 

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Poly-L-lysine-blended chitosan, collagen-blended chitosan and albumin-blended chitosan were also considered, with collagen control material. Culture of PC12 cells and fetal mouse cerebral cortex cells on these biomaterials was used to evaluate their nerve cell affinity. The composite materials, had significantly improved nerve cell affinity compared to chitosan. Poly-L-lysine-blended chitosan exhibited the best nerve cell affinity and was a better material in promoting neurite outgrowth than collagen [328]. 

Jose MV et al (2009) Fabrication and characterization of aligned nanofibrous PLGA/Collagen blends as bone tissue scaffolds. Polymer 50(15) 3778-3785... 

Cromoist. [Croda Inc. Croda Chem. Ltd.] Hydrolyzed collagen blends moisturizer, conditioner for skin care prods. 

Oleo-CoiL [Brodcs Industries] Hydrolyzed collagen blends for skin and hair care cosmetics. 

Figure 15.1 Schematic sketch of the electrospinning setup used for producing fibers with diameters in the micro/nanometer range. As an example of electrospinning application to cationic polymers, SEM images of (A) hydroxybutyl chitosan (HBC) nanofibers and (B) HBC/collagen blend nanofibers are shown. Both scaffolds are essentially constituted by fiber sizes in the nanometer range and can be handled without tearing. (Adapted from Dang and Leong with permission from Wiley-VCH.)...

An alternative approach involves blending of conducting polymers with biomaterials of interest to form biocomposites. This, of course, ideally involves the TCP and biomolecule to be soluble in a compatible solvent that does not denature the biomolecule. Such examples are limited and usually involve polyanilines [26], as they are more postsynthesis processable. ICP polyanilines have, for example, been blended with collagen. Blending of poly(o-ethoxyaniline) and collagen resulted in formation of flexible free-standing semiconducting materials. 

Cell growth When seeded on electrospun fibrous coUagen-blended or elastin/collagen-blended polyurethane scaffolds, the growth of smooth muscle cells (SMCs) increased by 283% and 224%, respectively. Wong et al. Composition... 

Sionkowska A, Kaczmaiek H, Wisniewski M, El-Feninat F, Mantovani D. Ultraviolet irradiation of synthetic polymer/collagen blends preliminary results of atomic force microscopy. In Mantovani D, editor. Advanced materials for biomedical applications. Quebec Canadian Institute of Mining, Metallurgy and Petroleum 2002. p. 27-40. 

Lima, A.M., Cerqueira, M. A., Souza, B.W.S., Santos, Ed.C.M.,Teixeira, J.A., Moreira, R.A. and Vicente, A.A. (2010). New edible coatings composed of galactoman-nans and collagen blends to improve the postharvest quality of fruits. Journal of Food Engineering, 97(1), 101-109. 

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