Infants colic

Simeticone is an antifoaming agent that relieves flatulence and is used in infant colic. 

Children Safety and efficacy are not established. Hyoscyamine has been used in infant colic. Safety and efficacy of giycopyrroiate in children younger than 12 years of age are not established for peptic ulcer. Dicyciomine is contraindicated in infants younger than 6 months of age. 

Smooth muscle relaxant activity. Tine-ture of the gland, administered to rabbits, was active on the bladder and intestine " . Toxic effect. Gum, administered orally to adults, was active. A case of methemoglobinemia occurred in a 5-week-old male infant, after administration of asafetida preparation to alleviate colic. Treatment was with intravenous methylene blue and the infant recovered . Tumor-promoting activity. Water extract of the dried oleoresin, administered externally to mice at a dose of 200 pL/animal, was active vs 7,12-dimethylbenz[a]anthra-cene and croton oil treatment ". ... 

N.A. Carvone, limonene, flavonoids, coumarins, xanthones, triterpenes.99,100,107 Used for infant colic, cough, cold and flu remedies. It relieves digestive disorders. 

Chinese star anise (I. verum Hook, F.) is a well-known spice used in the treatment of infant colic. Japanese star anise [I. anisa-tum L.), however, has been documented to have both neurologic and gastrointestinal toxicities. 

Patients with mild cases of HS often do not need any treatment. However, these patients should be watched carefully for the development of hemolytic or aplastic crisis. Splenectomy is the treatment of choice in moderate-to-severe HS cases. In general, splenectomy is indicated in patients who are continuously anemic or who have a history of gallstone colic or repeated crises. The clinical results of splenectomy for HS are almost uniformly excellent. However, splenectomy in very young children should be postponed to later in childhood because splenectomized infants are more susceptible to serious and potentially lethal infections than are older children and adults. At the time of splenectomy, it is important to identify and remove any accessory spleen otherwise, the operation will... 

Clyne PS, Kulczycki A, Jr. Human breast milk contains bovine IgG. Relationship to infant colic Pediatrics 1991 87(4) 439-44. 

Cohort study A study in which a group of people with a past exposure to chemical substances or other risk factors are followed over time and their disease experience compared to that of a group of people without the exposure Colic Acute abdominal pain, especially in infants... 

Illicium anisatum contains sesquiterpenoids, such as anisatin, anisotin, neoanisatin, and pseudoanisatin. Illicium religiosum (Japanese star anise) contains shikimic acid, anisatin and neoanisatin. Illicium verum (Chinese star anise) contains the monoterpenoid transanethole. Chinese star anise has been used to treat infant colic, but can be confused with Japanese star anise, which contains the neurotoxin anisatin. 

Therapeutically, oral doses of 125-250 mg of simethicone, three or four times daily, have been given as an antiflatulent. Doses of 20-40 mg of simethicone have been given with feeds to relieve colic in infants. ... 

Metcalf TJ, Irons TG, Sher LD, Young PC. Simethicone in the treatment of infant colic randomized, placebo-controlled, multi-center trial. Pediatrics 1994 84 29—34. 

Chamomile (Matricaria recutita) Chamomile is dried flower heads used in herbal tea for relief of digestive and gastrointestinal (GI) disruptions and infant colic. Chamomile has a sedative effect. Chamomile can cause hives and bronchoconstriction in patients who are allergic to daisy or ragweed. 

Chamomile is dried flower heads used in herbal tea for relief of digestive and GI disruptions and infant colic. Chamomile has a sedative effect. 

B. Neonatal drug withdrawal may occur In infants with chronic prenatal exposure to illicit or therapeutic drugs. The onset is usually within 72 hours of birth, but a postnatal onset as late as 14 days has been reported. Signs usually commence in the nursery, and infants are not discharged until clinically stable. However, with early discharge from nurseries becoming the norm, an infant in withdrawal may first present to an emergency department or acute care clinic. The presentation may be as mild as colic or severe as withdrawal seizures or profound diarrhea. 

Kurt TL et al Fatal iatrogenic iodine toxicity in a nine-week old infant. J Toxicol Clin Toxicol 1996 34(2) 231-234. [PMID 8618260] (A 9-week-okJ infant with colic was given an enema using so mL of povidone-iodine diluted in 250 mL of a bowel irrigant, resulting in fatal corrosive necrosis of the lower Gl trad and total blood iodine level of 14,600 mcg/dL.)... 

Mennella and Beauchamp 1991 Mennella and Beauchamp 1993). As with some commonly consumed vegetables, such as broccoli and cabbage, garlic consumption by nursing mothers has been associated with colic in some breastfeeding infants (Lust et al. 1996). 

Lust, K.D., J. Brown, and W. Thomas. 1996. Maternal intake of cmciferous vegetables and other foods and colic symptoms in exclusively breast-fed infants. /. Am. Diet. Assoc. 96(l) 46-48. 

A risk-benefit analysis on the use of fennel tea as a colic remedy for infants indicated that studies regarding carcinogenicity of the compound estragole in animal studies were difficult to interpret, as direct translation of animal experimental data to humans is problematic for numerous reasons. The analysis concluded that, based on available clinical and epidemiological data, any cancer risk is negligible and fennel seed is safe for use in infants (Iten and Sailer 2004). 

Since animal studies had demonstrated that the essential oil of F. vulgare reduced intestinal spasm and increased the motility of the small intestine, it was used in a double-blind, randomized, placebo-controlled trial in the treatment of infantile colic. The 125 infants were all 2-12 weeks of age and those in the treatment group received a water emulsion of 0.1% fennel essential oil and 0.4% poly-sorbate (5-20 mL) up to four times a day. The dose was estimated to provide about 12 mg/kg/day of fennel essential oil. The control group received the polysorbate only. The treatment provided a signi cant improvement of colic, eliminating symptoms in 65% of infants as compared to 23.7% for the control. No side effects were noted (Alexandrovich et al., 2003). 

Szajewska H, Gju czuk E, Horvath A. Lactobacillus reuteri DSM 17938 for the management of infantile colic in breastfed infants a randomized, double-blind, placebo-controlled trial. J Pediatr. 2013 162 257-262. 

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