Coleus

Forskolin is a diteipene derivative from the plant Coleus forskohlii. It activates all mammalian isozymes of adenylyl cyclase except AC9 and AC 10. 

Riiedi, P Eugster, C. H. Struktur von Coleon E, einem neuen ditepenoiden Methylenchinon aus der Coleus barbatus-Gruppe (Labiatae). Helv. Chim. Acta 1972, 55, 1994-2014. 

Coleus blumei cell suspension cultures 0.0005 rosmarinic acid-50 (52) ... 

CLOVER, white sweet (MtHlotus alba Desr.) COLEUS (Coleus blumei Benth.)... 

Coleus blumei Rosmarinic acid Polyphenol Anti-inflammatory... 

Some new diterpenoid oxides have been obtained from Eupatorium jhanii. They are jhanol (12) and its 18-acetate together with jhanidiol (13) and its 18-monoacetate and diacetate. Their structures were established by correlation with manoyl oxide and by an examination of their C n.m.r. spectra. 11/3-Hydro-xymanoyl oxide (14) has been isolated from Juniperus oxycedrus ° A group of new 11-oxomanoyl oxide derivatives (15a—e) has been obtained from Coleus forskohlii (Labiatae). Their oxygenation pattern is reminiscent of that of the tricyclic diterpenoids which have beemobtained from other Coleus species. 

Burger, J. and Edwards, G.E., Photosynthetic efficiency, and photodamage by UV and visible radiation, in red versus green leaf coleus varieties, Plant Cell Physiol, 37, 395, 1996. 

Salvia divinorum contiene un diterpene, salvinorin. Si parla di composti simili ritrovati in qualche specie di Coleus ma non se ne ha ancora alcuna conferma (i rapporti di laboratorio sono per lo piu negativi)... 

An early report by Epi ing and Jativa (1962) showing that S. divinorum was most closely allied to S. concolor Lamb ex. Benth led us to screen this species for salvinorin A content. Ethnobotanical reports suggesting that Coleus blumei was similarly used as a psychotropic by the Mazatec (Wasson, 1962) caused us to screen one sample of this species as well for possible content of 1. HPLC analysis of the leaf extracts of these two species did not show any salvinorin A present, nor was 1 found in leaf extracts of S. blepharophylla, S. chiapensis, S. gregii var. San Isidro, S. leucantha, S. membranacea or S. re cun-a. 

Salvia divinorum is, in the minds of the Mazatecs, only the most important of several plants, all Labiatae, that they regard as members of the same "family." Salvia divinorum is known as la hemhra, "the female." El macho, or "the male" is Coleus pumila, of European origin. Then there is el nene, "the child," and el ahijado, "the godson," which are both forms of Coleus Blumei. Some Indians insist that these others are likewise psychotropic, but we have not tried them others say these are merely medicinal. 

It would seem, in summary, that we are on the threshold of the discovery of a complex of psychotropic plants in the Eabiatae of Mint Family. We know that Salvia divinorum is so employed in the Sierra Mazateca, and Coleus pumila and two "forms" of C. Blumei are said by some of the Indians to be similiarly used. 

VALDES III J.L. et al., 1987b, Coleus barbatus C.forskohlii) (Lamiaceae), and the potential new drug forskolin (coleonol), Econ.Bot., 41(4) 474-483. 

The aerial parts of Conyza steudellii (Asteraceae) have given new labdane xylosides, while from the leaves of Conyza trihecatactis, a xylopyranoside of 13-epi-sclareol has been isolated among other labdanes [104,105]. Havardic acids A-F (as methyl esters), have been isolated from another genus of the Asteraceae family, i.e Grindelia havardii [106]. 11-oxo-manoyl oxide derivatives and coleosol, which is also a manoyl oxide derivative, have been obtained from Coleus forskohlii (Labiateae) [107,108] while from another plant of the Labiatae family, Roylea calycina a tumor inhibitory compound, namely precalyone, as well as calyone have been isolated [109]. 

The most important manoyl oxide derivative is forskolin (9), Fig. (7), (7p-acetoxy-8, 13-epoxy-la, 6p, 9a-trihydroxylabd-14-en-ll-one) [151-153]. It belongs to the labdane series of diterpenes and was isolated from the Indian herb Coleus forskohlii (Willd.) Briq. (Labiatae). Since ancient times it has been used in Hindu and Ayurvedic traditional medicine [154]. The plant Coleus forskohlii (Willd.) Briq. has been extensively studied, and from its extracted roots a group of diterpenoids, with the basic skeleton of 11-oxo-manoyl oxide, have been isolated. The main compound, forskolin, presented remarkable chemical and biological properties [155]. Analogues of forskolin were then prepared by semisynthesis [156] or obtained by microbial transformations [157]. New analogues, more soluble than forskolin have shown activities comparable to and even higher than forskolin [158]. 

Most products containing Coleus Forskohlii should be (but rarely actually are) standardized for a 10% forskolin content. An effective dosage of the 10% standardized product has been 165-250 MG, 3-4 times daily. So far there is some existing research that supports the listed effects of Coleus Forskohlii. And anecdotal /personal evaluations are positive thus far. It seems finding an actual standardized source is the most difficult aspect of acquiring favorable results. 

The use of Coleus Forskohlii seems to have possible cardiovascular benefits by acting as a vasodilator (lowers blood pressure), inhibition of platelet aggregation (reduced blood clotting), and positive inotropic activity in the heart (increased contractile force). 

The use of Coleus Forskohlii does not seem to inhibit endogenous TSH production. There is a synergy between this product and beta-andrenergic drugs such as Clenbuterol, ephedrine, synephrine, and norephedrine. 

Some athletes used guggulsterones to regenerate thyroid function after discontinuance of synthetic T-3/T-4 protocols. Those who thought ahead, utilized guggulsterones " synthetic T-3/T-4 thyroid hormone use to prevent thyroid function suppression even temporarily. This usually was initiated 10-14 days prior to synthetic thyroid administration discontinuance. Coleus Forskohlii, the amino acid tyrosine, and iodine also had a noted great deal of value for this purpose. 

T-2 use can create a negative feedback loop at higher dosages and due to prolonged use. The result was often metabolic lag usually for 3-7 days after discontinuance. (See guggulsterones and Coleus Forskohlii for common reported... 

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