Forskolin, which is isolated from Coleus forskohlii, stimulates adenylate cyclase

FIGURE 52 Forskolin, which is isolated from Coleus forskohlii, stimulates adenylate cyclase. 

Fosamprenavir is a protease inhibitor. Fosamprenavir is a prodrug of amprenavir that inhibits HIV protease, the enzyme required to form functional proteins in HIV-infected patients. It is indicated in the treatment of HIV infections in combination with other antiretroviral agents. 

Foscamet is an antiviral agent that inhibits replication of all known herpes viruses, including cytomegalovirus (CMV), herpes simplex virus types 1 and 2 (HSV-1, HSV-2), human herpes virus 6 (HHV-6), Epstein-Barr virus (EBV) and varicella-zoster virus (VZV). It is indicated in the treatment of CMV retinitis in patients with AIDS treatment of acyclovir-resistant mucocutaneous HSV infections in immunocompromised patients and as combination therapy with ganciclovir for patients who have relapsed after monotherapy with either drug. 

Clinical trials have demonstrated long-term virologic benefit in treatment-naive patients receiving amprenavir (1200 mg every 12 hours) in combination with zidovudine and lamivudine. Similar resnlts are seen when amprenavir is combined with ritonavir. 

Fosfomycin is antiinfective/antiseptic in natnre. It interferes with bacterial cell-wall biosynthesis. It is indicated in the treatment of nncomplicated UTI (acute cystitis) in women cansed by snsceptible strains of specihc microorganisms. 

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Forskolin, which is isolated from Coleus forskohlii, stimulates adenylate cyclase. Choleragen, the secretory product of Vibrio cholerae, can persistently activate adenylate cyclase by catalyzing the transfer of the ADP-ribose moiety of nicotinamide adenine dinucleotide (NAD+) to (see also Figure 52). 

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