Cold drugs

Hall, S., Teen abuse of cold drug on the rise many pharmacies relocate Coricidin behind tire counter, Detroit News, p. 1A, March 14, 2002. 

During the Second World War, Union Chimique Beige started producing basic pharmaceuticals such as calcium, phosphor, vitamins, insulin, and sulfamides. However, it was only in the late fifties that it launched, with limited market impact, its first real pharmaceutical products - Postafene (an anti-histamine), Atarax (a tranquilizer) and Tuclase (a cough and cold drug) - and concluded a first license agreement with Pfizer for the distribution of Atarax in the U.S. 

Cantu C, Arauz A, MuriUo-BoniUa LM, Lopez M, Barinagarrementeria F. Stroke associated with sympatho-mimetics contained in over-the-counter cough and cold drugs. Stroke 2003 34(7) 1667-72. 

Tatsuzawa et aq 36,37,45,59 separat.ed cold drugs and neuroleptics by using a styrene-divinyl benzene-methyl methacrylate copolymer as stationary phase. The best results were obtained with methanol - ammonia (99 1) as mobile phase. The effect of the pH and of the composition of the mobile phase on the separation were discussed. Aramaki et al.70 analyzed a series of alkaloids on a macroporous styrene-divinylbenzene copolymer with alkaline acetonitrile - water mixtures as mobile phase (Fig. 7.10). The columns showed excellent stability, and also under the strong basic conditions used for the analysis of the alkaloids. 

Ebbo M, Benarous L, Thomas G, Jourde N, Genot S, Bernit E, Veit V, Harle JR, Schleinitz N. Posterior reversible encephalopathy syndrome induced by a cough and cold drug containing pseudoephedrine. Rev Med Interne 2010 31 (6) 440-4. 

Starch is insoluble in cold water, but in hot water the granules gelatinize to form an opalescent dispersion. It is made from corn, wheat, potatoes, rice and other cereals by various physical processes such as steeping, milling and sedimentation. It is used as an adhesive, for sizing paper and cloth, as an inert diluent in foods and drugs, and for many other purposes. 

Acetophenone is a colourless compound, havtng m.p. 20° and b.p. 201° except in cold weather it is therefore usually a liquid, of dy I 03. It has only a faint odour. Acetophenone was at one time used medicinally under the name of hypnone as a soporific, but for this purpose it has now been largely superseded by other and more suitable drugs. 

Decoction The required amount of drug is placed in cold water and heated to boiling it is allowed to boil for a short while (mostly 5--10 min.) and after standing for a short while strained. This procedure is particularly suitable for hard to very hard drugs (woods, roots, barks), especially when they contain tannins., e.g. ratanhia root, etc. 

Drugs against the common cold may be designed from the structure of rhinovirus... 

Do not expose a drug to excessive sunlight, heat, cold, or moisture because deterioration may occur. 

In addition, the nurse determines if any controllable factors (eg, uncomfortable position, cold room, drafts, bright lights, noise, thirst) may be decreasing the patient s tolerance to pain. If these factors are present, the nurse corrects them as soon as possible. However, Hie nurse should not deny pain drugs or make the patient wait for the drug. Pain medication is delivered in a timely manner. 

Older adultsare at increased risk for adverse reactions when taking the (3-adrenergic blocking drugs The nurse should monitor the older adult closely for confusion, heart failure, worsening of angina, shortness of breath, and peripheral vascular insufficiency (eg, cold extremities paresthesia of the hands weak peripheral pulses). 

Do not use any nonprescription drug (eg, cold or flu preparations or nasal decongestants) unless use of a specific drug has been approved by the primary care provider. 

Avoid alcohol and nonprescription drug s unless their use has been approved by the primary health care provider. Hypertensive patients should be careful to avoid medications that increase blood pressure, such as over-the-counter drag s for appetite suppression and cold symptoms. 

Discontinue die use of tiiis drug and notify die primary healdi care provider if any of the following occur skin rash, metallic taste in die mouth, swelling and soreness in front of die ears, sore teetii and gums, severe gastrointestinal distress, or symptoms of a head cold. 

Warns that drug may feel cold when inserted. 

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