Cohen, William

Hyde LA, Zhang Q, Del Vecchio RA, Leach PT, Cohen-Williams ME, Chen L et al (2013) In vivo characterization of a novel y-secretase inhibitor SCH 697466 in rodents and investigation of strategies for managing notch-related side effects. Int J Alzheimers Dis. doi 10.1155/2013/823528... 

Laser Cooling The 1997 Nobel Prize in physics was shared by Steven Chu of Stanford University, William D. Phillips of the National Institute of Science and Technology, and Claude N. Cohen-Tannoudje of the College de France for their development and theoretical explanation of laser cooling, a process that can lower the temperature of a gas to a very low value. 

Newman, William Royall. "The background to Newton s chemistry." In The Cambridge companion to Newton, eds. I. Bernard Cohen and George E. Smith, 358-369. Cambridge Cambridge Univ P, 2002. 

Submitted by Peyton C. Teague and William A. Short.1 Checked by Arthur C. Cope, John C. Sheehan, and Louis A. Cohen. 

Bross PF, Cohen MH, Williams GA, Pazdur R (2002) FDA drug approval summaries fulvestrant. Oncologist 7 477-480... 

American Society of Heating, Refrigeration and Air Conditioning Engineers — H. R. Kornblum Chemical Manufacturers Association — D. R. Frikken Copper Development Association — A. Cohen Ductile Iron Pipe Research Association — T. F. Stroud Edison Electric Institute — R. L. Williams International District Heating Association — G. M. Von Bargen... 

Cohen, P. S., Arruda, J. C., Williams, T. J., and Laux, D. C. (1985). Adhesion of a human fecal Escherichia coli strain to mouse colonic mucus. Infect. Immun. 48,139-145. 

Cohen, M. H., Williams, G. A., Sridhara, R., et al. (2004) United States Food and Drug Administration drug approval summary gefitinib (ZD1839 Iressa) tablets. Clin Cancer Res. 10, 1212-1218. 

Garrett CR, Fishman MN, Rago RR, Williams CC, Dellaportas AM, Mahany JJ, Lush RM, Dalton WS, Gollerkeri A, Cohen MB, Sullivan DM. (2005) Phase 1 study of a novel taxane BMS-188797 in adult patients with solid malignancies. Clin Cancer Res 11 3335-3341. 

Cohen MH, Williams GA, Sridhara R, Chen G, McGuinn WD Jr, Morse D, Abraham S, Rahman A, Liang C, Lostritto R, Baird A, Pazdur R (2004) Clin Cancer Res 10 1212... 

M. H. Cohen, G.A. Williams, R. Sridhara, G. Chen, R. Pazdur, FDA drug approval summary Gefitinib (ZD1839) (Iressa(R)) Tablets, Oncologist 8 (2003) 303-306. 

Miguel, E.C., do Rosario-Campos, M.C., Shavitt, R.G., Hounie, A.G., and Mercandante, M.T., (2001) The tic-related obsessive-compulsive disorder phenotype and treatment implications. In Cohen, D.J., Jankovic, J., Goetz, C., eds. Tourette Syndrome and Associated Disorders (Adv Neurol Yol 85). Philadelphia Lippin-cott-Williams Wilkins, pp. 43-56. 

Following oral administration, coumarin is rapidly absorbed from the gastrointestinal tract and is distributed throughout the body (Cohen, 1979 Fentem Fry, 1993 Pelkonen et al., 1997 Lake, 1999). The compound is extensively metabolized in all species, with little excretion of unchanged coumarin. No significant tissue accumulation of coumarin and/or coumarin metabolites occurred after oral administration to rats and rabbits (Kaighen Williams, 1961) or intraperitoneal administration to rats (van Sumere Teuchy, 1971). 

There are important quantitative differences between species in the routes of elimination of coumarin metabolites. In rats, biliary excretion occurs with an appreciable proportion of the dose excreted in the faeces (Cohen, 1979 Lake, 1999). For example, after a 50-mg/kg bw oral or intraperitoneal dose of coumarin to rats, some 50% was excreted in the bile as unknown metabolites within 24 h (Williams et al., 1965). The urine appears to be the major route of coumarin excretion in Syrian hamsters, rabbits and baboons, but not in marmosets (Kaighen Williams, 1961 Waller Chasseaud, 1981 Lake et al, 1989a, 1990 Lake, 1999). 

In December 1997, Secretary of Defense William Cohen announced a departmentwide anthrax immunization program for high-risk military personnel. Implementation began in March 1998. On May 18, 1998, the Secretary authorized the vaccination of all military forces (Cohen, 1998). Almost 2.5 million troop-equivalent doses of vaccine were required to implement the Secretary s decision, much more than had ever been produced by the licensed manufacturer in its entire history. Prior to Desert Storm, the primary vaccine users had been veterinary, laboratory, and industrial workers at risk of infection, for whom an estimated 60,000 doses of Anthrax Vaccine Absorbed (AVA) were distributed between 1974 and 1989, an average of 4,533 doses per year (foellenbeck et al., 2002). During Desert Storm, approximately 150,000 troops received 300,000 doses of AVA, without accurate recording of recipients or adverse reactions. 

Gardner, Eliot L., William Paredes, Diane Smith, Thomas Seeger, Amy Donner, Cassandra Milling, David Cohen, and David Morrison. 1988. "Strain-Specific Facilitation of Brain Stimulation Reward by AMetrahydrocannabinol in Laboratory Rats." Psychopharmacology 96(suppl] 365. 

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