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Coenzyme A functions

In the above reaction CoASH stands for coenzyme A (Figure 13-7), and it contains the vitamin pantothenic acid (Chapter 38). Coenzyme A functions as a carrier of... [Pg.236]

Both these pools are apparently supplied from the same sources of COgt and the primary products of photochemical reactions, occuring in the membrane of thylakoids. But judging by the isoprene production /14, 16/ the pool AcCoA, presumably is supplied by them in lesser degree than pool BC. Further it. is supposed that the pool AcCoA, beside the main function - the biosynthesis of acetate which than is activated by coenzyme A functions as a supplier of phosphogly ceric acid in chloroplast (Ch) which can be synthesized from... [Pg.3004]

Hydrolysis of the phosphate ester function of the phosphatidic acid gives a diacylglycerol which then reacts with a third acyl coenzyme A molecule to produce a triacylglycerol... [Pg.1078]

Section 27 21 Often the catalytically active functions of an enzyme are nothing more than proton donors and proton acceptors In many cases a protein acts m cooperation with a coenzyme, a small molecule having the proper func tionahty to carry out a chemical change not otherwise available to the protein itself... [Pg.1152]

The electrodeposited film of flavin derivatives would be utilized as a functional material in combination with number dehydrogenases and pyridine coenzymes for the detection of great number of analytes. [Pg.363]

Certain amino acids and their derivatives, although not found in proteins, nonetheless are biochemically important. A few of the more notable examples are shown in Figure 4.5. y-Aminobutyric acid, or GABA, is produced by the decarboxylation of glutamic acid and is a potent neurotransmitter. Histamine, which is synthesized by decarboxylation of histidine, and serotonin, which is derived from tryptophan, similarly function as neurotransmitters and regulators. /3-Alanine is found in nature in the peptides carnosine and anserine and is a component of pantothenic acid (a vitamin), which is a part of coenzyme A. Epinephrine (also known as adrenaline), derived from tyrosine, is an important hormone. Penicillamine is a constituent of the penicillin antibiotics. Ornithine, betaine, homocysteine, and homoserine are important metabolic intermediates. Citrulline is the immediate precursor of arginine. [Pg.87]

The preferred substrates of acetyltransferases are amino-groups of antibiotics, like chloramphenicol, strepto-gramin derivatives, and the various aminoglycosides. The modification is believed to block a functional group involved in the drug-target-interaction. All acetyltransferases use acetyl-coenzyme A as cofactor. [Pg.104]

NAD and NADP and FMN and FAD, respectively. Pantothenic acid is a component of the acyl group carrier coenzyme A. As its pyrophosphate, thiamin participates in decarboxylation of a-keto acids and folic acid and cobamide coenzymes function in one-carbon metabolism. [Pg.51]

Pantothenic acid has a central role in acyl group metabolism when acting as the pantetheine functional moiety of coenzyme A or acyl carrier protein (ACP) (Figure 45-18). The pantetheine moiety is formed after combination of pantothenate with cysteine, which provides... [Pg.495]

ACE-I, angiotensin-converting enzyme inhibitors ARB, angiotensin-receptor blockers AZA, azathioprine CMV, cytomegalovirus CPK, creatinine phos-phokinase CSA, cyclosporine HMG-CoA, 3-hydroxy 3-methylglutaryl coenzyme A reductase K+, potassium LFTs, liver function tests Rl, renal insufficiency SCr, serum creatinine SRL, sirolimus TAC, tacrolimus TMP-SMX, trimethoprim-sulfamethoxazole. [Pg.847]

Garlic s proven mechanisms of action include (a) inhibition of platelet function, (b) increased levels of two antioxidant enzymes, catalase and glutathione peroxidase, and (c) inhibition of thiol enzymes such as coenzyme A and HMG coenzyme A reductase. Garlic s anti-hyperlipidemic effects are believed to be in part due to the HMG coenzyme A reductase inhibition since prescription medications for hyperlipidemia have that mechanism of action (statins). It is unknown whether garlic would have the same drug interactions, side effects, and need for precautions as the statins. [Pg.738]

Mononuclear Ni complexes have been investigated as functional models for individual steps of the reactions mediated by the CODH/acetyl coenzyme A synthase.2018-2020 These are mentioned in the respective sections on mononuclear Ni complexes. The dinuclear type (770) complexes are... [Pg.447]

Acetylcholine synthesis and neurotransmission requires normal functioning of two active transport mechanisms. Choline acetyltransferase (ChAT) is the enzyme responsible for ACh synthesis from the precursor molecules acetyl coenzyme A and choline. ChAT is the neurochemical phenotype used to define cholinergic neurons although ChAT is present in cell bodies, it is concentrated in cholinergic terminals. The ability of ChAT to produce ACh is critically dependent on an adequate level of choline. Cholinergic neurons possess a high-affinity choline uptake mechanism referred to as the choline transporter (ChT in Fig. 5.1). The choline transporter can be blocked by the molecule hemicholinium-3. Blockade of the choline transporter by hemicholinium-3 decreases ACh release,... [Pg.129]

Many substances which are necessary (and even essential) for life functions contain sulphur for example, the amino acids cysteine and methionine, the tripeptide glutathione or coenzyme A (CoA), with the latter containing the SH group of cys-teamine as the terminal functional group. CoA acts as a coenzyme in all important biochemical acylations. The cysteamine SH group bonds to carboxylic acids to give thioesters ... [Pg.205]

The presence of a PHA synthase alone is not sufficient to allow synthesis of PHAs. PHA biosynthesis will not occur if genes encoding enzymes required for the synthesis of hydroxyacyl-coenzyme A thioesters are absent or if the pathways constituted by these enzymes are for whatever reason not functionally active. This becomes evident, for example, when a PHA synthase gene is expressed in wild type or normal laboratory strains of E. coir, even if a functionally active PHA synthase is expressed, no or only traces of PHAs are accumulated. [Pg.103]

There are an overwhelming number of studies which successfully demonstrated heterologous expression of PHA synthesis genes in bacteria it will therefore not be possible to mention them all. Establishment of functional active PHA biosynthesis pathways in E. coli requires not only a PHA synthase but also enzymes that allow the conversion of metabolites, which derive from the provided carbon source, into the R isomers of hydroxyacyl-coenzyme A thioesters that are used as a substrate by the respective PHA synthase. Otherwise, no or only marginal amounts of PHAs are accumulated. [Pg.111]

Gould and coworkers have extensively studied the biosyntheses of the kinamycins, and this work was recently reviewed [5a]. Feeding studies established that the carbo-cyclic skeletons of the kinamycins are constructed from 10 equivalents of 5-acetyl coenzyme A, and the pathway shown in Scheme 3.4 was proposed. The pathway begins with formation of the natural product dehydrorabelomycin (29). A novel ring contraction then occurs to form the cyclopentadienone 30. Feeding studies with /V-15-ammonium sulfate established that the diazo functional group is then installed... [Pg.45]

Another observation on oxalate formation is that other a-keto acids, such as oxalosuccinic acid (74) and a-ketoglutaric acid (106) do not seem to yield oxalate directly but indirectly (123). This appears to be due to the fact that only oxaloacetic acid can function as an acetate donor. In this connection the intervention of Coenzyme A may be considered, since it is reported to function in the acetylation of sulfanilamide and choline (73) and recently was shown to take part in the enzymatic synthesis of citric acid. This concept may be illustrated as follows ... [Pg.77]

A secondary goal is to reduce proteinuria and renal function decline seen with administration of statins (3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors). [Pg.875]

The hydrogenation of ketones with O or N functions in the a- or / -position is accomplished by several rhodium compounds [46 a, b, e, g, i, j, m, 56], Many of these examples have been applied in the synthesis of biologically active chiral products [59]. One of the first examples was the asymmetric synthesis of pantothenic acid, a member of the B complex vitamins and an important constituent of coenzyme A. Ojima et al. first described this synthesis in 1978, the most significant step being the enantioselective reduction of a cyclic a-keto ester, dihydro-4,4-dimethyl-2,3-furandione, to D-(-)-pantoyl lactone. A rhodium complex derived from [RhCl(COD)]2 and the chiral pyrrolidino diphosphine, (2S,4S)-N-tert-butoxy-carbonyl-4-diphenylphosphino-2-diphenylphosphinomethyl-pyrrolidine ((S, S) -... [Pg.23]

Coenzymes complement the catalytic action of the amino-acid functional groups. They are bound to apoenzymes (apoproteins) either covalently or non-covalently. It is interesting to note that non-covalently-bound coenzymes are polyanions at neutral pH as exemplified by the structures of glutathione (GSH) [17] and thiamine pyrophosphate [18]. Shinkai and Kunitake (1976b, 1977a) demonstrated the efficient binding of glutathione and coenzyme A (a polyphosphate) to cationic micelles and cationic polysoaps. Thus, the combina- ... [Pg.446]


See other pages where Coenzyme A functions is mentioned: [Pg.832]    [Pg.171]    [Pg.832]    [Pg.171]    [Pg.645]    [Pg.93]    [Pg.379]    [Pg.645]    [Pg.593]    [Pg.380]    [Pg.495]    [Pg.195]    [Pg.71]    [Pg.91]    [Pg.117]    [Pg.19]    [Pg.231]    [Pg.254]    [Pg.544]    [Pg.1419]    [Pg.196]    [Pg.255]    [Pg.196]    [Pg.94]    [Pg.565]    [Pg.398]    [Pg.621]   
See also in sourсe #XX -- [ Pg.722 ]

See also in sourсe #XX -- [ Pg.722 ]

See also in sourсe #XX -- [ Pg.722 ]

See also in sourсe #XX -- [ Pg.722 ]

See also in sourсe #XX -- [ Pg.283 ]




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