Interactions drug-target

The various physicochemical interactions between a ligand and the target co-operate to estabhsh the target-drug interaction ... 

In the realm of drug discovery, the detection and characterization of target-ligand interactions is a critical process for lead identification, validation, and optimization. 

Acknowledgments Several review articles cover in much greater details numerous NMR applications that have been reported in the past years on the use of NMR spectroscopy in the drug discovery process and to monitor target-ligand interactions. The author apologizes if he was unable to mention properly all this work within the limited space of this article. 

Ethic variations in medication responses include differences in therapeutic responses and susceptibility to adverse effects. Such differences are attributable mostly to two aspects, the variation of enzyme activities for the metabolism of medications, and variations of the drugs interactions with target binding sites. 

G. Poste, R. Kirsh, and T. Koestler, eds. Liposome Technology. Targeted Drug Delivery and Biological Interactions, Vol. 3, CRC Press, Boca Raton, FL, 1984. 

Conformational variation in binding sites that attend catalysis and offer a multiplicity of distinct opportunities for drug interactions with the target molecule in a manner leading to abolition of biological function. 

A rational approach to problems such as drug targeting to regions protected by P-gp, inhibition or even prevention of multidrug resistance in different organisms, and prediction of drug-drug interactions due to P-gp should become possible with reliable structure-activity relationship (SAR) studies. 

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