Cocaine mixed with alcohol

It did, of course, cure many addicts of their addiction to morphine or alcohol—they instead quickly became addicted to cocaine. Freud had advocated that cocaine be taken orally, a method that would have enabled some of the cocaine to be broken down in the liver before it reached the brain, resulting in a less intense experience of euphoria. But in the 1880s the use of the syringe was perfected, and soon hypodermic needles were more widely available. Morphine addicts quickly began injecting themselves with cocaine or cocaine mixed with morphine. It... 

Physical effects of high doses of ketamine include decreased respiration and heart rate, increased blood pressure, and the possibility of vomiting and convulsions. These can lead to cardiac and respiratory arrest, coma, and death. The risk of ketamine overdose is much greater when it is mixed with other drugs such as alcohol, Ecstasy, caffeine, or cocaine. Overdoses of ketamine have been reported when people boost the drug (take another dose before the first dose wears off) to prolong its psychedelic effects. 

In some parts of North America, for instance, the following combinations are found Candy sticks cannabis herb cigarettes laced with cocaine Buddha cannabis herb spiked with opium Ace or Zoom cannabis herb mixed with PCP, etc. use of cannabis in food items (e.g. in North Africa ) Marijuana brownies (e.g. in North America) as well as frequent use of both cannabis and alcohol (often reported from Europe and Australia). 

The leaves are exhausted with 85% alcohol and acidulated with 2% of sulfuric acid the tincture is treated with milk of lime and filtered the filtrate is neutralized with sulfuric acid, and the alcohol distilled off. The syrupy residue is treated with water to separate resin and then precipitated by sodium carbonate. The deposited matter is exhausted by ether, and the etheral solution, after most of the ether has been distilled, is allowed to evaporate spontaneously. The cocaine is thus obtained in colorless crystals, mixed with a yellowish-brown matter of a disagreeable odor, which is separated by washing with cold alcohol. 

Cocaine is a CNS stimulant that affects blood vessels and pupils, and increases body temperature, heart rate, and blood pressure. The euphoric effects of cocaine are quick and include reduced fatigue and mental clarity, as well as hyperstimulation. Research reports that the faster the absorption, the shorter the duration of action. The effects of cocaine in humans are variable (e.g., feeling of restlessness, irritability, and anxiety). Cocaine has powerful neuropsychological-reinforcing properties that are responsible for its repeated compulsive use. In some cases, the first dose may prove fatal. Cocaine-related death may be due to cardiac arrest or convulsion followed by respiratory arrest. In drug abuse, people mix cocaine with alcohol, leading to a chemical complex called cocaethylene, which intensifies the euphoria but can culminate in death. 

Benzoylation.—Distilled methyl-ecgonine dissolved in benzene is mixed with a small excess of benzoyl chloride, and the mixture heated at its boiling point under a reflux condenser. The cocaine hydrochloride obtained on cooling is converted to base and is purified by recrystallisation from alcohol. The hydrochloride is then re-formed and recrystallised from mixtures of alcohol and light petroleum or ether. Recrystallisation must be repeated, if necessary, until the pharmacopoeial tests of purity are complied with, since associated impurities are apt to possess dangerous toxic properties. 

Methamphetamine is often combined with other illegal drugs. A common combination is mixing methamphetamine with heroin, either in an injection or in smoking. This mixture is called a speedball. Methamphetamine users will also mix in cocaine to increase the initial rush. Methamphetamine addicts are often alcoholics. 

Coca leaves were brought to Europe by the Spanish conquistadores, and cocaine was isolated from the leaves in the 1860s. In 1863, the French chemist Angelo Mariani created the tonic Vin Mariani , an extract of coca in Bordeaux wine. The non-alcoholic version Coca-Cola was invented in 1886 by the American Pharmacist John Pemberton, who mixed extracts of coca leaves and caffeine-containing cola nuts with soda. With the introduction of the first anti-drug laws in the USA in 1906, however, only decocainized leaves were used for the production of Coca-Cola. 

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