Mixing and extraction

It is satisfactory to use the Super-Cel brand of kieselguhr supplied by Johns-Manville Company and asbestos of the type used in Gooch crucibles. Inclusion of these inert materials facilitates mixing and extraction of the product. 

Procedure. Dissolve a suitable weight of the sample of lead in 6M nitric acid add a little 50 per cent aqueous tartaric acid to clear the solution if antimony or tin is present. Cool, transfer to a separatory funnel, and dilute to about 25 mL. Add concentrated ammonia solution to the point where the slight precipitate will no longer dissolve on shaking, then adjust the pH to 1, using nitric acid or ammonia solution. Add 1 mL freshly prepared 1 per cent cupferron solution, mix, and extract with 5 mL chloroform. Separate the chloroform layer, and repeat the extraction twice with 1 mL portions of cupferron solution + 5 mL of chloroform. Wash the combined chloroform extracts with 5mL of water. Extract the bismuth from the chloroform by shaking with two 10 mL portions of 1M sulphuric acid. Run the sulphuric acid solution into a 25 mL graduated flask. Add 3 drops saturated sulphur dioxide solution and 4 mL of 20 per cent aqueous potassium iodide. Dilute to volume and measure the transmission at 460 nm. 

Place a portion of capsules contents or place a volume of syrup, equivalent to about 250 mg of valproic acid, in a separator. Add 20 mL of 1.0 M sodium hydroxide shake and allow the layers to separate. Transfer the aqueous layer to a second separator, add 4.0 mL of hydrochloric acid, mix, and extract with 40 mL -heptane. Filter the w-heptane layer through glass wool into a beaker, and evaporate the... 

FIGURE 3 Common devices for mixing and extraction Scientific Industries (Vortex Genie 2), Burrell wrist-action shaker and Branson 8510 sonicator. 

Sleicher, C. A., Axial mixing and extraction efficiency. AJ.ChJE. Journal 5, 145 (1959). 

Acid Ether Extract Add 5 mL of 3 A hydrochloric acid to the extracted colorant solution set aside in the alkaline ether extract procedure above, mix, and extract with ether as directed above. Wash the ether extract with two 25-mL portions of 0.1 N hydrochloric acid and water. Transfer the washed ether in portions to the flask containing the evaporated alkaline extract, and carefully remove all the ether by distillation. Dry the residue in an oven at 85° for 20 min. Then allow the flask... 

Digest the samples overnight at 37°C, and then dilute to 240 pL by adding 205 pL of 10 mM Tris-HCl, and 1 mMEDTA, pH 7.6. Mix and extract once with an equal volume of phenolxhloroform. 

IS solution in aqueous 75% methanol is vortex mixed with 0.05 M Na2C03 Serum is added and the resulting mixture is again vortex mixed and extracted with ethyl acetate... 

The extraction of Bi chelates occurs generally with methyl isobutyl ketone (MIBK), i.e., 5 mL heparinized blood, 5 mL distilled water, 0.2 mL 10% aqueous solution of Triton X-100, and 5 mL 1% ammonium pyrrolidine dithiocarbamate in water are mixed and extracted with 3 mL MIBK [102]. A similar method is also reported with lower volumes [48]. 

In a 2-litre round-bottomed flask, equipped with a double surface condenser, place 60 g. of triniethylene dicyanide (Section 111,114) and 900 g. of 50 per cent, sulphuric acid (by weight). Reflux the mixture for 10 hours and allow to cool. Saturate the solution with ammonium sul phate and extract wit-h four 150 ml. portions of ether dry the ethereal extracts with anhydrous sodium or magnesium sulphate. Distil off the ether on a water bath the residual glutaric acid (69 g.) crystallises on cooling and has m.p. 97-97-5°. Upon recrystalhsation from chloroform, or benzene, or benzene mixed with 10 per cent, by weight of ether, the m.p. is 97 -5-98°. 

Ethyl phenylethylmalonate. In a dry 500 ml. round-bottomed flask, fitted with a reflux condenser and guard tube, prepare a solution of sodium ethoxide from 7 0 g. of clean sodium and 150 ml. of super dry ethyl alcohol in the usual manner add 1 5 ml. of pure ethyl acetate (dried over anhydrous calcium sulphate) to the solution at 60° and maintain this temperature for 30 minutes. Meanwhile equip a 1 litre threenecked flask with a dropping funnel, a mercury-sealed mechanical stirrer and a double surface reflux condenser the apparatus must be perfectly dry and guard tubes should be inserted in the funnel and condenser respectively. Place a mixture of 74 g. of ethyl phenylmalonate and 60 g. of ethyl iodide in the flask. Heat the apparatus in a bath at 80° and add the sodium ethoxide solution, with stirring, at such a rate that a drop of the reaction mixture when mixed with a drop of phenolphthalein indieator is never more than faintly pink. The addition occupies 2-2 -5 hoius continue the stirring for a fiuther 1 hour at 80°. Allow the flask to cool, equip it for distillation under reduced pressure (water pump) and distil off the alcohol. Add 100 ml. of water to the residue in the flask and extract the ester with three 100 ml. portions of benzene. Dry the combined extracts with anhydrous magnesium sulphate, distil off the benzene at atmospheric pressure and the residue under diminished pressure. C ollect the ethyl phenylethylmalonate at 159-160°/8 mm. The yield is 72 g. 

Hey That really wasn t a lot of work. Just a lot of talk on Strike s part. All one did was mix an oil with some acid, added water and isolated. One gets some pure propenylbenzene without distillation. Done on a massive scale, this is a cheap method for getting lots of small concentration allylbenzene compounds out of complex oil mixes. And since Strike blew so much dough on this glorified extraction protocol, someone better damn well use it (In an academic lab of course). 

When completed, the solution is merely dumped into 1L of dH20 and extracted 3 x lOOmL Et20 or DCM or benzene. BUT when that solution hits the solvent, the biggest, ugliest emulsion Strike has ever hypothesized occurs. It is wicked The chemists can try all the usual tricks to get rid of that bitch, but when it comes down to it, there is only one way that works. The chemist is going to have to extract with hundreds upon hundreds of mLs of solvent. The idea here is to saturate both the aqueous and emulsion layer with so much solvent that a separate solvent layer can form. Once saturated, the entire mix can then be properly extracted. 

A solution of 2,3-dimethylindole (145 g, 1 mol) in dry dioxan containing hydroquinone (100 mg) was treated with JV,JV,JV-trimethylbenzylammonium ethoxide (5 ml of a 40% solution in MeOH) and warmed to 35 C. Freshly distilled acrylonitrile (150 ml, 2.5 mol) was added at a rate such that the temperature did not rise above 40°C. The solution was then stirred overnight and diluted with 10% aq. acetic acid (11). The solution was extracted with CH Clj and the extract was washed with water and dried (MgS04). extract was then mixed with silica gel (800 g) and the solvent removed in vacuo. The silica was placed in a Soxhlet extractor and extracted with cyclohexane. The extract deposited the product as colourless needles (125 g, 63% yield). 

The General Mills mixer—settler (117), shown in Figure 13b, is a pump—mix unit designed for hydrometaHurgical extraction. It has a baffled cylindrical mixer fitted in the base and a turbine that mixes and pumps the incoming Hquids. The dispersion leaves from the top of the mixer and flows into a shallow rectangular settler designed for minimum holdup. 

RoUer-top cards have five to seven sets of workers and strippers to mix and card the fibers carried on the cylinder. The multiple transferring action and re-introduction of new groupings of fibers to the carding zones provides a doubling effect which enhances web uniformity. Stationary-top cards have strips of metallic clothing mounted on plates positioned concavely around the upper periphery of the cylinder. The additional carding surfaces thus estabhshed provide expanded fiber alignment with minimum fiber extraction. 

Mixed mono- and dialkyl are used as catalysts for resin curing and as intermediates for fire retardants, oil additives, antistatic agents (qv), and extraction solvents. An equimolar mixture of mono- and dialkyl acid phosphates are formed at a 1 6 mole ratio of oxide to alcohol. 

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